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Titolo:
Clinicopathological comparisons of familial and sporadic cases in 219 consecutive Japanese epithelial ovarian cancer patients
Autore:
Sagawa, T; Yamashita, Y; Fujimoto, T; Yamada, H; Hoshi, N; Sakuragi, N; Fujimoto, S;
Indirizzi:
Hokkaido Univ, Sch Med, Dept Obstet & Gynecol, Sapporo, Hokkaido 0608638, Japan Hokkaido Univ Sapporo Hokkaido Japan 0608638 oro, Hokkaido 0608638, Japan
Titolo Testata:
JAPANESE JOURNAL OF CLINICAL ONCOLOGY
fascicolo: 11, volume: 29, anno: 1999,
pagine: 556 - 561
SICI:
0368-2811(199911)29:11<556:CCOFAS>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
GERM-LINE MUTATIONS; BRCA1 GENE; HEREDITARY; CARRIERS; BREAST; RISK; HETEROGENEITY; FEATURES; REGISTRY; WOMEN;
Keywords:
familial ovarian cancer; breast ovarian cancer syndrome; hereditary nonpolyposis colorectal cancer; epithelial ovarian cancer;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Sagawa, T Hokkaido Univ, Sch Med, Dept Obstet & Gynecol, Kita 15 Jo Nishi 7 Chome, Sapporo, Hokkaido 0608638, Japan Hokkaido Univ Kita 15 Jo Nishi 7 Chome Sapporo Hokkaido Japan 0608638
Citazione:
T. Sagawa et al., "Clinicopathological comparisons of familial and sporadic cases in 219 consecutive Japanese epithelial ovarian cancer patients", JPN J CLIN, 29(11), 1999, pp. 556-561

Abstract

Background: It is estimated that approximately 5-10% of epithelial ovariancancer patients in Western countries are associated with an autosomal dominant inheritance with variable penetrance. There are a few reports of familial ovarian cancer in Japan and considerable uncertainties remain regardingJapanese familial ovarian cancer. The aim of this study was to clarify theclinicopathological features of Japanese familial ovarian cancer. Methods: We studied clinicopathological findings for 219 consecutive epithelial ovarian cancer patients treated at our institution from April 1987 toSeptember 1997. Results: Eleven patients in nine families were diagnosed as familial ovarian cancer and the incidence of familial cases was 5.0%. Most women (90.9%) with familiar cases were diagnosed as the breast ovarian cancer syndrome, whereas ovarian cancer associated with hereditary nonpolyposis colorectal cancer was relatively rare (9.1%). Serous adenocarcinoma, high histological grade, advanced FIGO stage and breast cancer as multiple primary cancer weresignificantly more common in familial cases compared with sporadic cases (p < 0.001, p < 0.05, p < 0.005 and p < 0.005, respectively). Earlier age ofonset was thought to be a characteristic of familial ovarian cancer in Western countries; however, we did not find any difference in age at diagnosisbetween familial and sporadic Gases (53.4 vs 51.3 years). The prognosis offamiliar ovarian cancer remains controversial and our data did not show a significant difference (p = 0.45) in prognosis between these two groups. Conclusion: These findings, except for age at diagnosis, in Japanese familial ovarian cancer are in accordance with the features of familial ovarian cancer in Western countries.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 14:19:54