Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Targeting chemotherapy to solid tumors with long-circulating thermosensitive liposomes and local hyperthermia
Autore:
Ishida, O; Maruyama, K; Yanagie, H; Eriguchi, H; Iwatsuru, M;
Indirizzi:
Teikyo Univ, Sch Pharmaceut Sci, Dept Pharmaceut, Kanagawa 1990195, Japan Teikyo Univ Kanagawa Japan 1990195 t Pharmaceut, Kanagawa 1990195, Japan Univ Tokyo, Inst Med Sci, Dept Clin Oncol, Minato Ku, Tokyo 1080071, JapanUniv Tokyo Tokyo Japan 1080071 in Oncol, Minato Ku, Tokyo 1080071, Japan
Titolo Testata:
JAPANESE JOURNAL OF CANCER RESEARCH
fascicolo: 1, volume: 91, anno: 2000,
pagine: 118 - 126
SICI:
0910-5050(200001)91:1<118:TCTSTW>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
LARGE UNILAMELLAR LIPOSOMES; POLY(ETHYLENE GLYCOL); INVIVO; TIME; DOXORUBICIN; ADRIAMYCIN; DELIVERY; VESICLES; BEHAVIOR; BLOOD;
Keywords:
targeting chemotherapy; hyperthermia; thermosensitive liposomes; long-circulating liposomes; polyethyleneglycol;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Maruyama, K Teikyo Univ, Sch Pharmaceut Sci, Dept Pharmaceut, Kanagawa 1990195, Japan Teikyo Univ Kanagawa Japan 1990195 , Kanagawa 1990195, Japan
Citazione:
O. Ishida et al., "Targeting chemotherapy to solid tumors with long-circulating thermosensitive liposomes and local hyperthermia", JPN J CANC, 91(1), 2000, pp. 118-126

Abstract

The effectiveness of the combination of long-circulating, thermosensitive liposomes and hyperthermia is described. Small-sized, thermosensitive liposomes that encapsulate doxorubicin (DXR-PEG-TSL (SUV)) have a prolonged circulation time and are extravasated to targeted solid tumors in vivo, where they preferentially release the agent in an anatomical site subjected to local hyperthermia, Liposomes were prepared by the incorporation of amphipathic polyethyleneglycol (PEG) to prolong their circulation time. DXR-PEG-TSL (SUV) was retained longest and was accumulated mast efficiently in solid tumors in Balb/c mice. The combination of DXR-PEG-TSL (SUV) and hyperthermia at the tumor sites 3 h after injection, gave high concentrations of doxorubicin in tumor tissue and resulted in more effective tumor retardation and increased survival time. A large amount of DXR-PEG-TSL (SUV) was extravasatedinto the tumors during circulation for 3 h after injection, suggesting that the encapsulated drug was released into the interstitial spaces of the lesions by local hyperthermia. This system is expected to be clinically valuable for the delivery of a wide range of chemotherapeutic agents in the treatment of solid tumors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 06:15:26