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Titolo:
Oncolytic viruses
Autore:
Nemunaitis, J;
Indirizzi:
PRN Res Inc, Dallas, TX USA PRN Res Inc Dallas TX USAPRN Res Inc, Dallas, TX USA Baylor Univ, Med Ctr, Dallas, TX USA Baylor Univ Dallas TX USABaylor Univ, Med Ctr, Dallas, TX USA
Titolo Testata:
INVESTIGATIONAL NEW DRUGS
fascicolo: 4, volume: 17, anno: 1999,
pagine: 375 - 386
SICI:
0167-6997(1999)17:4<375:OV>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEWCASTLE-DISEASE-VIRUS; HERPES-SIMPLEX VIRUS; VACCINIA MELANOMA ONCOLYSATE; ACTIVE SPECIFIC IMMUNOTHERAPY; HUMAN BREAST-CANCER; ADENOVIRUS-MEDIATED TRANSFER; AUTOLOGOUS TUMOR-CELLS; II MALIGNANT-MELANOMA; GENE-THERAPY; ADJUVANT IMMUNOTHERAPY;
Keywords:
viruses; oncolytic; lysis; malignant;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
128
Recensione:
Indirizzi per estratti:
Indirizzo: Nemunaitis, J PRN Res Inc, Dallas, TX USA PRN Res Inc Dallas TX USAPRN Res Inc, Dallas, TX USA
Citazione:
J. Nemunaitis, "Oncolytic viruses", INV NEW DR, 17(4), 1999, pp. 375-386

Abstract

Viruses capable of inducing lysis of malignant cells through their replication process are known as "oncolytic" viruses. Clinical trials in oncology have been performed with oncolytic viruses for nearly fifty years. Both systemic and intratumoral routes of administration have been explored. Toxicity has generally been limited to injection site pain, transient fever and tumor necrosis. Responses with early crude materials were usually short in duration; however, recent trials with gene attenuated viruses suggest more prolonged duration to responses observed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 17:23:14