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Titolo:
Sequential development of airway hyperresponsiveness and acute airway obstruction in a mouse model of allergic inflammation
Autore:
Neuhaus-Steinmetz, U; Glaab, T; Daser, A; Braun, A; Lommatzsch, M; Herz, U; Kips, J; Alarie, Y; Renz, H;
Indirizzi:
Inst Lab Med & Pathobiochem Forsch Haus, Charite Campus Virchow Clin, D-13353 Berlin, Germany Inst Lab Med & Pathobiochem Forsch Haus Berlin Germany D-13353 , Germany State Univ Ghent, Dept Resp Dis, B-9000 Ghent, Belgium State Univ Ghent Ghent Belgium B-9000 pt Resp Dis, B-9000 Ghent, Belgium Univ Pittsburgh, Dept Environm & Occupat Hlth, Pittsburgh, PA USA Univ Pittsburgh Pittsburgh PA USA onm & Occupat Hlth, Pittsburgh, PA USA
Titolo Testata:
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
fascicolo: 1, volume: 121, anno: 2000,
pagine: 57 - 67
SICI:
1018-2438(200001)121:1<57:SDOAHA>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMMEDIATE HYPERSENSITIVITY; AIRBORNE CHEMICALS; RESPIRATORY-TRACT; IGE PRODUCTION; BRONCHIAL RESPONSIVENESS; MURINE MODEL; T-CELLS; MICE; HYPERREACTIVITY; ASTHMA;
Keywords:
plethysmography; methacholine; inflammation, allergic; tidal breathing; ovalbumin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Renz, H Inst Lab Med & Pathobiochem Forsch Haus, Charite Campus Virchow Clin, Augustenburger Pl 1, D-13353 Berlin, Germany Inst Lab Med & Pathobiochem Forsch Haus Augustenburger Pl 1 Berlin Germany D-13353
Citazione:
U. Neuhaus-Steinmetz et al., "Sequential development of airway hyperresponsiveness and acute airway obstruction in a mouse model of allergic inflammation", INT A AL IM, 121(1), 2000, pp. 57-67

Abstract

Background: Mouse models have been established mirroring key features of human bronchial asthma including airway hyperresponsiveness (AHR). Acute airway obstruction in response to an allergen challenge, however, remains to be demonstrated in these models. Objective: A mouse model of allergic lung inflammation was employed to analyze the development of specific (allergen-induced) and nonspecific (methacholine-induced) airway obstruction. Methods:Mice were sensitized to ovalbumin (OVA) and challenged with OVA aerosol twice each week during four weeks. Changes in lung functions were determined by noninvasive head-out body plethysmography. The development of acute airway obstruction after OVA challenge and AHR after methacholine aerosol application were assessed by a decrease in the mid-expiratory flow rate (EF50) Results: Two airway challenges were sufficient to induce AHR (5.7 vs. 15 mg/ml methacholine). Further OVA challenges reduced the baseline EF50 from 1.85 to 1.20 ml/s (4th week) and induced acute airway obstruction. The OVA-induced obstruction was maximal in the 4th week (EF50 = 0.91 ml/s). Conclusion: The development of acute airway obstruction in allergen-sensitized mice was demonstrated by means of head-out body plethysmography. In our model, AHR was observed before the development of airway obstruction. Copyright (C) 2000 S. Karger AG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 16/02/20 alle ore 20:59:20