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Titolo:
Graft-versus-host-disease-associated donor cell engraftment in an F-1 hybrid model is dependent upon the Fas pathway
Autore:
Iwasaki, T; Hamano, T; Saheki, K; Kuroiwa, T; Kataoka, Y; Takemoto, Y; Ogata, A; Fujimoto, J; Kakishita, E;
Indirizzi:
Hyogo Med Univ, Dept Internal Med 2, Nishinomiya, Hyogo 6638501, Japan Hyogo Med Univ Nishinomiya Hyogo Japan 6638501 miya, Hyogo 6638501, Japan Hyogo Med Univ, Dept Surg 1, Nishinomiya, Hyogo 6638501, Japan Hyogo Med Univ Nishinomiya Hyogo Japan 6638501 miya, Hyogo 6638501, Japan
Titolo Testata:
IMMUNOLOGY
fascicolo: 1, volume: 99, anno: 2000,
pagine: 94 - 100
SICI:
0019-2805(200001)99:1<94:GDCEIA>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; HEMATOPOIETIC PROGENITOR CELLS; BONE-MARROW; T-CELLS; MEDIATED APOPTOSIS; IMMUNE-RESPONSES; FACTOR-ALPHA; EXPRESSION; MICE; LYMPHOCYTES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Iwasaki, T Hyogo Med Univ, Dept Internal Med 2, 1-1 Mukogawa Cho, Nishinomiya, Hyogo 6638501, Japan Hyogo Med Univ 1-1 Mukogawa Cho Nishinomiya HyogoJapan 6638501
Citazione:
T. Iwasaki et al., "Graft-versus-host-disease-associated donor cell engraftment in an F-1 hybrid model is dependent upon the Fas pathway", IMMUNOLOGY, 99(1), 2000, pp. 94-100

Abstract

The graft-versus-host disease (GVHD) generated in BDF1 mice by the injection of spleen cells from the C57BL/6 parental strain induces a direct cell-mediated attack on host: lymphohaematopoietic populations, resulting in the reconstitution of the host with donor cells. We examined Fas-Fas ligand (FasL) interactions in donor and host haematopoietic cells over a prolonged period of parental-induced GVHD. Fas expression on bone marrow cells of both donor and host origin increased at 2 weeks. Host cell incubation with anti-Fas antibody induced apoptosis, and the number of haematopoietic progenitorcells decreased. Fas-induced apoptosis by the repopulating donor cells, however, did not increase until 12 weeks, when more than 90% of the cells were donor cells. The expression of various cytokines, such as interferon-gamma (IFN-gamma) and tumour necrosis factor-alpha (TNF-alpha), and Fast gene expression in the bone marrow increased concomitantly. To examine directly whether Fast has a major role in the development of donor cell engraftment, FasL-deficient (gld) mice were used as donors. Injection of B6/gld spleen cells induced significantly less host lymphohaematopoietic depletion, resulting in a failure of donor cell engraftment. Furthermore, injection of IFN-gamma gene knockout (gko) B6 spleen cells failed to augment: Fas and Fast expression in recipient mice, resulting in a failure of donor cell engraftment. This suggests that the induction of apoptosis by Fas-FasL interactions in host cells may contribute to a reconstitution of the host with donor cells and that donor-derived IFN-gamma plays a significant role for Fas-FasL interactions in host cells during parental-induced GVHD.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 00:55:28