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Titolo:
Differential expression of dihydropyrimidinase-related protein genes in developing and adult enteric nervous system
Autore:
Inagaki, H; Kato, Y; Hamajima, N; Nonaka, M; Sasaki, M; Eimoto, T;
Indirizzi:
Nagoya City Univ, Sch Med, Dept Pathol, Mizuho Ku, Nagoya, Aichi 4678601, Japan Nagoya City Univ Nagoya Aichi Japan 4678601 Nagoya, Aichi 4678601, Japan Nagoya City Univ, Sch Med, Dept Biochem, Mizuho Ku, Nagoya, Aichi 4678601,Japan Nagoya City Univ Nagoya Aichi Japan 4678601 , Nagoya, Aichi 4678601,Japan Nagoya City Univ, Sch Med, Dept Pediat, Mizuho Ku, Nagoya, Aichi 4678601, Japan Nagoya City Univ Nagoya Aichi Japan 4678601 Nagoya, Aichi 4678601, Japan Univ Tokyo, Grad Sch Sci, Dept Biol Sci, Tokyo 1130033, Japan Univ Tokyo Tokyo Japan 1130033 Sci, Dept Biol Sci, Tokyo 1130033, Japan
Titolo Testata:
HISTOCHEMISTRY AND CELL BIOLOGY
fascicolo: 1, volume: 113, anno: 2000,
pagine: 37 - 41
SICI:
0948-6143(200001)113:1<37:DEODPG>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
AXONAL GUIDANCE; SEMAPHORIN-III; UNC-33; OUTGROWTH; FAMILY; RECEPTOR; CRMP-2; ULIP; RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Inagaki, H Nagoya City Univ, Sch Med, Dept Pathol, Mizuho Ku, Nagoya, Aichi 4678601, Japan Nagoya City Univ Nagoya Aichi Japan 4678601 chi 4678601, Japan
Citazione:
H. Inagaki et al., "Differential expression of dihydropyrimidinase-related protein genes in developing and adult enteric nervous system", HISTOCHEM C, 113(1), 2000, pp. 37-41

Abstract

Dihydropyrimidinase-related proteins (DRPs) are involved in axonal outgrowth and pathfinding. However, little is known about their significance in the enteric nervous system (ENS), the largest and most complex division of the peripheral nervous system. Using in situ hybridization (ISH) and northernblotting, we examined mRNA expression of DRP-1-4 transcripts in the developing and adult mouse digestive tract and in the adult human colon. ISH detected the mouse DRP-3 transcript in the developing ENS on embryonic day (E)12 and at the later stages as well as in the adult intestine. Mouse DRP-1 and -2 transcripts appeared at E14. DRP-2 transcript was also detected in theadult intestine although DRP-1 expression was lower in the adult. DRP-4 gene was not expressed in the ENS during development or adulthood whereas thesignal was apparent in the developing and adult central nervous system (CNS). The DRP expression pattern in the human colon was similar to that of the mouse large intestine. Northern blot analysis showed that DRPs were differentially expressed in the mouse and human intestines, supporting the results of ISH. These data suggest that DRPs play a role not only in the CNS butalso in the ENS.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/04/20 alle ore 08:42:35