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Titolo:
Hematopoiesis and cytokines - Relevance to cancer and aging
Autore:
Baraldi-Junkins, CA; Beck, AC; Rothstein, G;
Indirizzi:
Univ Utah, Salt Lake City GRECC, Div Geriatr, Salt Lake City Vet Adm Med Ctr,Sch Med, Salt Lake City, UT 84148 USA Univ Utah Salt Lake City UT USA 84148 h Med, Salt Lake City, UT 84148 USA
Titolo Testata:
HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA
fascicolo: 1, volume: 14, anno: 2000,
pagine: 45 -
SICI:
0889-8588(200002)14:1<45:HAC-RT>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
AGE-ASSOCIATED DECLINE; T-CELL SUBSETS; COLONY-STIMULATING FACTOR; MESSENGER-RNA EXPRESSION; MULTIPLE-MYELOMA CELLS; TUMOR-NECROSIS-FACTOR; OLD MICE; INTERLEUKIN-2 RECEPTOR; LYMPHOKINE PRODUCTION; PROLIFERATIVE RESPONSE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
90
Recensione:
Indirizzi per estratti:
Indirizzo: Rothstein, G Univ Utah, Salt Lake City GRECC, Div Geriatr, Salt Lake City Vet Adm Med Ctr,Sch Med, 500 Foothills Blvd, Salt Lake City, UT 84148 USA Univ Utah 500 Foothills Blvd Salt Lake City UT USA 84148 USA
Citazione:
C.A. Baraldi-Junkins et al., "Hematopoiesis and cytokines - Relevance to cancer and aging", HEMAT ONCOL, 14(1), 2000, pp. 45

Abstract

Impaired hematopoiesis and dysregulated cytokine expression have importantimplications for cancer in the elderly in aged people, hematopoiesis is dysregulated and becomes paradoxically down-modulated under periods of increased hematopoietic demand. This down-modulation may explain, at least in part, the increased incidence of anemia in the elderly, although the cause of anemia can usually be identified in these patients and frequently reversed with targeted therapy. An age-associated decrease in the expression of interleukin-2 may contribute to impaired cellular immunity. Additionally the increased interleukin-6 production frequently found in the elderly may participate in promoting the survival and proliferation of malignant myeloma and in inducing resistance by myeloma cells to therapies that act through apoptosis. Dysregulation of the expression of these and other cytokines may be amechanism contributing to age-related impairment of the hematopoietic response, the genesis and therapeutic resistance of specific malignancies, and cancer cachexia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 16:39:31