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Titolo:
Segregation analysis of IgE levels in 335 French families (EGEA) using different strategies to correct for the ascertainment through a correlated trait (asthma)
Autore:
Sampogna, F; Demenais, F; Hochez, J; Oryszczyn, MP; Maccario, J; Kauffmann, F; Feingold, J; Dizier, MH;
Indirizzi:
Univ Paris 07, Lab Anthropol Biol, INSERM U155, F-75005 Paris, France UnivParis 07 Paris France F-75005 l, INSERM U155, F-75005 Paris, France INSERM U358, Paris, France INSERM U358 Paris FranceINSERM U358, Paris, France INSERM U472, Villejuif, France INSERM U472 Villejuif FranceINSERM U472, Villejuif, France
Titolo Testata:
GENETIC EPIDEMIOLOGY
fascicolo: 2, volume: 18, anno: 2000,
pagine: 128 - 142
SICI:
0741-0395(200002)18:2<128:SAOILI>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
TOTAL SERUM IGE; SKIN-TEST REACTIVITY; IMMUNOGLOBULIN-E; REGRESSIVE MODELS; MAJOR GENE; INHERITANCE; ALLERGENS; LINKAGE; ATOPY; AGE;
Keywords:
immunoglobulin E; segregation analysis; regressive model; correction for ascertainment mode;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Dizier, MH Univ Paris 07, Lab Anthropol Biol, INSERM U155, Tour 16,3eme Etage,Case 7041,2 Pl Jussieu, F-75005 Paris, France Univ Paris 07 Tour 16,3eme Etage,Case 7041,2 Pl Jussieu Paris France F-75005
Citazione:
F. Sampogna et al., "Segregation analysis of IgE levels in 335 French families (EGEA) using different strategies to correct for the ascertainment through a correlated trait (asthma)", GENET EPID, 18(2), 2000, pp. 128-142

Abstract

The main objective of this study was to search for a major gene controlling total serum immunoglobulin E (IgE) levels, an intermediate phenotype for asthma and allergy. We studied 335 French nuclear families of the EGEA study (Epidemiological study of the Genetics and Environment of Asthma), ascertained through asthmatic probands (123 are parents in the family, 212 children). Segregation analyses were performed by regressive models, which can take into account a major gene effect, various sources of familial covariation (genetic and/or environmental) as well as measured risk factors (i.e., age, sex, smoking habits). Different strategies were considered to account for the mode of ascertainment of the families through a correlated trait (asthma): the ascertainment mode was either ignored (strategy A) or taken into account by adjusting IgE levels for the position in the family, i.e., probands, blood relatives, spouses (strategy B) or excluding the asthmatic children-probands and computing the likelihood of each family conditionally on parents' IgE levels (strategy C). Whereas a major gene effect could not be detected with strategy A, strategies B and C showed evidence for the transmission of a dominant major gene for high IgE levels, which was more significant with strategy B. This gene does not interact with any of the covariatesand is responsible for similar to 15% of IgE variation (the allele frequency is 0.65). Genet. Epidemiol. 18:128-142, 2000. (C) 2000 Wiley-Liss, Inc.

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Documento generato il 03/06/20 alle ore 09:45:50