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Titolo:
An experimental design study of interferences of clinical relevance of a polytyramine immobilized-enzyme biosensor
Autore:
Situmorang, M; Hibbert, DB; Gooding, JJ;
Indirizzi:
Univ New S Wales, Sch Chem, Sydney, NSW 2052, Australia Univ New S Wales Sydney NSW Australia 2052 m, Sydney, NSW 2052, Australia
Titolo Testata:
ELECTROANALYSIS
fascicolo: 2, volume: 12, anno: 2000,
pagine: 111 - 119
SICI:
1040-0397(200002)12:2<111:AEDSOI>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
ORTHOGONAL ARRAY DESIGN; AMPEROMETRIC GLUCOSE BIOSENSORS; CHEMOMETRIC METHOD; MICROWAVE DISSOLUTION; BIOLOGICAL SAMPLES; HYDROGEN-PEROXIDE; ELECTRON-TRANSFER; ASCORBIC-ACID; OXIDASE; OPTIMIZATION;
Keywords:
biosensor; electrodeposited polytyramine; immobilized enzyme; experimental design; interference;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Hibbert, DB Univ New S Wales, Sch Chem, Sydney, NSW 2052, Australia Univ New S Wales Sydney NSW Australia 2052 SW 2052, Australia
Citazione:
M. Situmorang et al., "An experimental design study of interferences of clinical relevance of a polytyramine immobilized-enzyme biosensor", ELECTROANAL, 12(2), 2000, pp. 111-119

Abstract

The use of a central composite experimental design to determine the extentof interferences of an enzyme biosensor is described. In contrast to methods that change the parameters to be optimized one-at-a-time, simultaneouslyvarying all parameters in a statistical design allows estimation of coefficients that describe interaction between the effects of the interferents and analyte. The analysis also gives the sensitivity (i.e., the slope of the current against concentration plot) for the analyte and interferents. The model system chosen was a glucose sensor in which glucose oxidase was immobilized in electrodeposited polytyramine, with interfering compounds of clinical relevance, uric acid, ascorbic acid and paracetamol. An electrode prepared by cyclic voltammetry of tyramine with three to fifteen cycles effectively reduced the level of interference.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 01:27:53