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Titolo:
An evaluation of endocrine modulators: Implications for human health
Autore:
Juberg, DR;
Indirizzi:
Amer Council Sci & Hlth, New York, NY 10023 USA Amer Council Sci & Hlth New York NY USA 10023 lth, New York, NY 10023 USA
Titolo Testata:
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
fascicolo: 2, volume: 45, anno: 2000,
pagine: 93 - 105
SICI:
0147-6513(200002)45:2<93:AEOEMI>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEX STEROID-LEVELS; BREAST-CANCER; ENVIRONMENTAL ESTROGENS; SEMEN QUALITY; PROSTATE-CANCER; MILL EFFLUENT; WHITE SUCKER; FEMALE RATS; PULP-MILLS; IN-VITRO;
Keywords:
endocrine disrupter; endocrine modulator; environmental estrogen;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
87
Recensione:
Indirizzi per estratti:
Indirizzo: Juberg, DR Amer Council Sci & Hlth, New York, NY 10023 USA Amer Council Sci & Hlth New York NY USA 10023 rk, NY 10023 USA
Citazione:
D.R. Juberg, "An evaluation of endocrine modulators: Implications for human health", ECOTOX ENV, 45(2), 2000, pp. 93-105

Abstract

The potential health risk of a group of chemicals, popularly known as "endocrine disrupters," has generated considerable scientific debate and media attention. The endocrine disrupter hypothesis asserts that exogenous substances with estrogenic or other hormonally active properties may adversely affect human health. Proponents of this hypothesis have associated endocrine modulators with negative outcomes such as cancer in hormonally sensitive tissues and declining sperm counts in men. However, the available laboratory,wildlife, and epidemiological data do not provide consistent or convincingevidence that industrial chemicals suspected of modulating estrogenic pathways are related to adverse health effects in humans. Both public and private initiatives are investigating chemicals labeled as endocrine disrupters for their relative hormonal activity. Screening assays aimed at assessing the endocrine activity or potential of a variety of substances should not beconfused with assessment of risk to humans, however. The latter entails not only hazard identification (the type of information that screening assaysare designed to provide), but also critical factors such as exposure analysis, potency assessment, and dose-response for individual chemicals, (C) 2000 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/09/20 alle ore 02:02:23