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Titolo:
Intra- and inter-individual correlations between cholecystokinin and corticotropin-releasing hormone concentrations in human cerebrospinal fluid
Autore:
Geracioti, TD; Ekhator, NN; Nicholson, WE; Arndt, S; Loosen, PT; Orth, DN;
Indirizzi:
Vet Adm Med Ctr, Psychiat Serv, Cincinnati, OH 45220 USA Vet Adm Med Ctr Cincinnati OH USA 45220 at Serv, Cincinnati, OH 45220 USA Univ Cincinnati, Coll Med, Dept Psychiat, Cincinnati, OH USA Univ Cincinnati Cincinnati OH USA Med, Dept Psychiat, Cincinnati, OH USA Vanderbilt Univ, Med Ctr, Dept Med, Div Endocrinol, Nashville, TN USA Vanderbilt Univ Nashville TN USA Med, Div Endocrinol, Nashville, TN USA Univ Iowa Hosp & Clin, Dept Psychiat, Iowa City, IA 52242 USA Univ Iowa Hosp & Clin Iowa City IA USA 52242 iat, Iowa City, IA 52242 USA
Titolo Testata:
DEPRESSION AND ANXIETY
fascicolo: 2, volume: 10, anno: 1999,
pagine: 77 - 80
SICI:
1091-4269(1999)10:2<77:IAICBC>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTERIOR-PITUITARY CELLS; PARAVENTRICULAR NUCLEUS; PANIC DISORDER; RATS; OCTAPEPTIDE; STIMULATION; VASOPRESSIN; ATTACKS; HEALTHY;
Keywords:
brain; central nervous system (CNS); cerebrospinal fluid (CSF); cholecystokinin (CCK); corticotropin-releasing hormone (CRH); corticotropin-releasing factor (CRF), depression; major depression; alcohol; alcoholism; alcohol dependence; anxiety;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Geracioti, TD Vet Adm Med Ctr, Psychiat Serv, 3200 Vine St, Cincinnati, OH45220 USA Vet Adm Med Ctr 3200 Vine St Cincinnati OH USA 45220 220 USA
Citazione:
T.D. Geracioti et al., "Intra- and inter-individual correlations between cholecystokinin and corticotropin-releasing hormone concentrations in human cerebrospinal fluid", DEPRESS ANX, 10(2), 1999, pp. 77-80

Abstract

Despite strong evidence of a physiologic relationship between cholecystokinin (CCK) and corticotropin-releasing hormone (CRH) in the mt central nervous system (CNS), evidence of such a relationship between the two hormones in the human CNS is lacking. A post hoc analysis of serial concentrations ofimmunoreactive CCK and CRH, obtained every ten minutes from CSF continuously collected over six hours, was performed. A total of 30 subjects were studied: 15 normal volunteers, 10 patients with major depression, and 5 recently-abstinent, alcohol-dependent patients. Overall, we observed an average intra-subject correlation of +.273 (P < 0.001) between CSF CRH and CCK. Intersubject correlations between mean CSF levels of CRH and CCK were +.948 (P = 0.0001) and +.959 (P = 0.005) in the depressed and abstinent alcoholic patients, respectively. These inter-individual correlations were significantly greater than that seen within the group of normal volunteers (r = +.318, n.s). The present data suggest that interactions between CCK and CRH are significant in the human CNS, particularly perhaps in depressed and alcoholicpatients, and that CSF samples may be used to assess elements of the relationship between these hormones. Published 1999 Wiley-Liss, Inc.dagger.

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Documento generato il 23/01/20 alle ore 03:45:55