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Titolo:
Structural studies of the translational apparatus
Autore:
Agrawal, RK; Frank, J;
Indirizzi:
SUNY Albany, Wadsworth Ctr, Albany, NY 12201 USA SUNY Albany Albany NY USA 12201 bany, Wadsworth Ctr, Albany, NY 12201 USA SUNY Albany, Howard Hughes Med Inst, Albany, NY 12201 USA SUNY Albany Albany NY USA 12201 ard Hughes Med Inst, Albany, NY 12201 USA SUNY Albany, Dept Biomed Sci, Albany, NY 12201 USA SUNY Albany Albany NY USA 12201 ny, Dept Biomed Sci, Albany, NY 12201 USA
Titolo Testata:
CURRENT OPINION IN STRUCTURAL BIOLOGY
fascicolo: 2, volume: 9, anno: 1999,
pagine: 215 - 221
SICI:
0959-440X(199904)9:2<215:SSOTTA>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
ESCHERICHIA-COLI RIBOSOME; ELONGATION-FACTOR-G; SARCIN-RICIN LOOP; CRYSTAL-STRUCTURE; A-SITE; 3-DIMENSIONAL STRUCTURE; ELECTRON CRYOMICROSCOPY; CRYOELECTRON MICROSCOPY; ANTIBIOTIC THIOSTREPTON; ANGSTROM RESOLUTION;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
56
Recensione:
Indirizzi per estratti:
Indirizzo: Agrawal, RK SUNY Albany, Wadsworth Ctr, Empire State Plaza, Albany, NY 12201 USA SUNY Albany Empire State Plaza Albany NY USA 12201 Y 12201 USA
Citazione:
R.K. Agrawal e J. Frank, "Structural studies of the translational apparatus", CURR OP STR, 9(2), 1999, pp. 215-221

Abstract

Significant progress is occurring at an accelerated rate in structural studies of ribosomes. A 3D cryoelectron microscopy map of the 70S ribosome from Escherichia coli is available at 15 Angstrom resolution and a combinationof cryoelectron microscopy with X-ray crystallography has yielded a 9 Angstrom resolution map of the 50S subunit from Haloarcula marismortui, an archaebacterium. For eukaryotes, 3D cryomaps of the 80S ribosomes from yeast and from mammals have now been produced at resolutions in the range 20 to 30 Angstrom. The most ground-breaking results have been obtained from the 3D mapping of ligands in functional studies of prokaryotic ribosomes. These studies, which directly visualize the protein synthesis machine in action, have brought new excitement to a field that was relatively dormant during the past decade.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 17:47:39