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Titolo:
Serum 1,25 dihydroxy vitamin D (1,25(OH)(2)D-3), 25 hydroxy vitamin D (25(OH)D) and parathormone levels in diabetic retinopathy
Autore:
Aksoy, H; Akcay, F; Kurtul, N; Baykal, O; Avci, B;
Indirizzi:
Ataturk Univ, Sch Med, Dept Biochem, TR-25240 Erzurum, Turkey Ataturk Univ Erzurum Turkey TR-25240 t Biochem, TR-25240 Erzurum, Turkey Ataturk Univ, Sch Med, Dept Ophthalmol, TR-25240 Erzurum, Turkey Ataturk Univ Erzurum Turkey TR-25240 phthalmol, TR-25240 Erzurum, Turkey
Titolo Testata:
CLINICAL BIOCHEMISTRY
fascicolo: 1, volume: 33, anno: 2000,
pagine: 47 - 51
SICI:
0009-9120(200002)33:1<47:S1DVD(>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
CANCER CELL-PROLIFERATION; HEPATOCYTE GROWTH-FACTOR; INSULIN-SECRETION; D DEFICIENCY; MELLITUS; 1,25-DIHYDROXYVITAMIN-D; DISEASE; ASIANS; INVIVO;
Keywords:
diabetic retinopathy; vitamin D; PTH;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Aksoy, H Ataturk Univ, Sch Med, Dept Biochem, TR-25240 Erzurum, Turkey Ataturk Univ Erzurum Turkey TR-25240 , TR-25240 Erzurum, Turkey
Citazione:
H. Aksoy et al., "Serum 1,25 dihydroxy vitamin D (1,25(OH)(2)D-3), 25 hydroxy vitamin D (25(OH)D) and parathormone levels in diabetic retinopathy", CLIN BIOCH, 33(1), 2000, pp. 47-51

Abstract

Objectives: To investigate whether there is a relationship between serum 1,25 dihydroxy vitamin D-3 [1,25(OH)(2)D-3] which is an inhibitor of angiogenesis, concentrations and severity of diabetic retinopathy (DR). Design and methods: Serum 1,25(OH)(2)D-3, 25 hydroxy vitamin D [25(OH)D] and parathormone (PTH) concentrations were measured in diabetic patients (n = 66) and nondiabetic healthy subjects (n = 20). Results: The mean serum 1,25(OH)(2)D-3 concentration in diabetic patients was lower than that in nondiabetics (57.3 +/- 21.44 vs 89.4 +/- 18.01 pmol/L, p < 0.001); mean 1,25(OH)(2)D-3 concentrations fell with increasing severity of DR [being 63.4 +/- 17.26 pmol/L for background DR (BDR), 47.7 +/- 13.27 pmol/L for preproliferative DR (pre-PDR), and 43.1 +/- 19.45 pmol/L for proliferative DR (PDR)]. Compared with the control group, serum 25(OH)D concentrations were found to be decreased in diabetic patients (p < 0.001). There were negative correlations between 1,25(OH)(2)D-3 and age (r = -0.331, p < 0.01) and duration of diabetes (r = -0.255, p < 0.05). Conclusion: From these findings, it was found that there was an inverse relationship between the severity of the retinopathy, i.e., neovascularization, and serum 1,25(OH)(2)D-3 concentrations, being the lowest in PDR and thehighest in diabetic patients without retinopathy (NDR) patients. The measurement of serum 1,25(OH)(2)D-3 concentrations might be helpful to predict severity of DR in patients with diabetes mellitus. Copyright (C) 2000 The Canadian Society of Clinical Chemists.

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Documento generato il 13/07/20 alle ore 11:10:33