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Titolo:
Electron transfer in DNA from guanine and 8-oxoguanine to a radical cationof the carbohydrate backbone
Autore:
Meggers, E; Dussy, A; Schafer, T; Giese, B;
Indirizzi:
Univ Basel, Dept Chem, CH-4056 Basel, Switzerland Univ Basel Basel Switzerland CH-4056 pt Chem, CH-4056 Basel, Switzerland
Titolo Testata:
CHEMISTRY-A EUROPEAN JOURNAL
fascicolo: 3, volume: 6, anno: 2000,
pagine: 485 - 492
SICI:
0947-6539(20000204)6:3<485:ETIDFG>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
HETEROLYTIC C,O-BOND CLEAVAGE; STRAND CLEAVAGE; 4'-DNA RADICALS; AQUEOUS-SOLUTION; DISTANCE; CHEMISTRY; SCISSION; RIBONUCLEOSIDES; DEPENDENCE; INSULATOR;
Keywords:
DNA oxidation; DNA radicals; electron transfer; oxoguanine; radical ions;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
57
Recensione:
Indirizzi per estratti:
Indirizzo: Giese, B Univ Basel, Dept Chem, St Johanns Ring 19, CH-4056 Basel, Switzerland Univ Basel St Johanns Ring 19 Basel Switzerland CH-4056 tzerland
Citazione:
E. Meggers et al., "Electron transfer in DNA from guanine and 8-oxoguanine to a radical cationof the carbohydrate backbone", CHEM-EUR J, 6(3), 2000, pp. 485-492

Abstract

Photolysis of a 4'-pivaloyl-substituted nucleotide in single- and double-stranded DNA (1) generated an enol ether radical cation 4 that was reduced to enol ether 17 by electron transfer from the nearest guanoside (G). Variation of the nucleotide sequence demonstrated a strong distance dependence ofthis electron-transfer rate with beta = 1.0 +/- 0.1 Angstrom(-1). When 8-oxoguanosine (G(oxo)) was used as the electron donor, the rate of the electron transfer increased by a factor of 4 but the distance dependence of the transfer remained unchanged within experimental error. In single strands, the number of intervening A, T, and C nucleotides had a much smaller effect; the rate remained nearly constant for two, three, or four intervening nucleotides. This is explained by the flexibility of the single-stranded oligonucleotides.

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Documento generato il 16/07/20 alle ore 19:54:10