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Titolo:
Characterization of muscle filamin isoforms suggests a possible role of gamma-filamin/ABP-L in sarcomeric Z-disc formation
Autore:
van der Ven, PFM; Obermann, WMJ; Lemke, B; Gautel, M; Weber, K; Furst, DO;
Indirizzi:
Univ Potsdam, Dept Cell Biol, D-14471 Potsdam, Germany Univ Potsdam Potsdam Germany D-14471 Cell Biol, D-14471 Potsdam, Germany Max Planck Inst Biophys Chem, Dept Biochem, D-3400 Gottingen, Germany Max Planck Inst Biophys Chem Gottingen Germany D-3400 Gottingen, Germany Max Planck Inst Mol Physiol, Dept Phys Biochem, D-44139 Dortmund, Germany Max Planck Inst Mol Physiol Dortmund Germany D-44139 9 Dortmund, Germany
Titolo Testata:
CELL MOTILITY AND THE CYTOSKELETON
fascicolo: 2, volume: 45, anno: 2000,
pagine: 149 - 162
SICI:
0886-1544(200002)45:2<149:COMFIS>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACTIN-BINDING PROTEIN; GLYCOPROTEIN IB-ALPHA; SKELETAL-MUSCLE; IMMUNOELECTRON MICROSCOPY; MYOSIN-BINDING; SMOOTH-MUSCLE; BIOCHEMICAL-CHARACTERIZATION; CYTOPLASMIC DOMAIN; TERMINAL REGION; HEART-MUSCLE;
Keywords:
ABP-280; filamin; ABPL; sarcomere; Z-disc; myofibrillogenesis; monoclonal antibody;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
57
Recensione:
Indirizzi per estratti:
Indirizzo: Furst, DO Univ Potsdam, Dept Cell Biol, Lennestr 7A, D-14471 Potsdam, Germany Univ Potsdam Lennestr 7A Potsdam Germany D-14471 tsdam, Germany
Citazione:
P.F.M. van der Ven et al., "Characterization of muscle filamin isoforms suggests a possible role of gamma-filamin/ABP-L in sarcomeric Z-disc formation", CELL MOTIL, 45(2), 2000, pp. 149-162

Abstract

Filamin, also called actin binding protein-280, is a dimeric protein that cross-links actin filaments in the cortical cytoplasm. In addition to this ubiquitously expressed isoform (FLN1), a second isoform (ABP-L/gamma-filamin) was recently identified that is highly expressed in mammalian striated muscles. A monoclonal antibody was developed, that enabled us to identify filamin as a Z-disc protein in mammalian striated muscles by immunocytochemistry and immunoelectron microscopy. In addition, filamin was identified as acomponent of intercalated discs in mammalian cardiac muscle and of myotendinous junctions in skeletal muscle. Northern and Western blots showed that both, ABP-L/gamma-filamin mRNA and protein, are absent from proliferating cultured human skeletal muscle cells. This muscle specific filamin isoform is, however, up-regulated immediately after the induction of differentiation. In cultured myotubes, ABP-L/gamma-filamin localises in Z-discs already atthe first stages of Z-disc formation, suggesting that ABP-L/gamma-filamin might play a role in Z-disc assembly.Cell Motil. (C) 2000 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 16:00:09