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Titolo:
Genomic imbalances including amplification of the tyrosine kinase gene JAK2 in CD30(+) Hodgkin cells
Autore:
Joos, S; Kupper, M; Ohl, S; von Bonin, F; Mechtersheimer, G; Bentz, M; Marynen, P; Moller, P; Pfreundschuh, M; Trumper, L; Lichter, P;
Indirizzi:
Deutsch Krebsforschungszentrum, Abt Org Komplexer Genome, D-69120 Heidelberg, Germany Deutsch Krebsforschungszentrum Heidelberg Germany D-69120 lberg, Germany Univ Saarlandes Kliniken, D-66421 Homburg, Germany Univ Saarlandes Kliniken Homburg Germany D-66421 -66421 Homburg, Germany Univ Heidelberg, Inst Pathol, D-69120 Heidelberg, Germany Univ HeidelbergHeidelberg Germany D-69120 , D-69120 Heidelberg, Germany Abt Innere Med 3, D-89081 Ulm, Germany Abt Innere Med 3 Ulm Germany D-89081 Innere Med 3, D-89081 Ulm, Germany Human Genome Lab, B-3000 Louvain, Belgium Human Genome Lab Louvain Belgium B-3000 ome Lab, B-3000 Louvain, Belgium Univ Ulm Klinikum, Abt Pathol, D-89081 Ulm, Germany Univ Ulm Klinikum Ulm Germany D-89081 , Abt Pathol, D-89081 Ulm, Germany
Titolo Testata:
CANCER RESEARCH
fascicolo: 3, volume: 60, anno: 2000,
pagine: 549 - 552
SICI:
0008-5472(20000201)60:3<549:GIIAOT>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
DISEASE; HYBRIDIZATION; LYMPHOMAS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Joos, S Deutsch Krebsforschungszentrum, Abt Org Komplexer Genome, H0700, D-69120 Heidelberg, Germany Deutsch Krebsforschungszentrum H0700 HeidelbergGermany D-69120 y
Citazione:
S. Joos et al., "Genomic imbalances including amplification of the tyrosine kinase gene JAK2 in CD30(+) Hodgkin cells", CANCER RES, 60(3), 2000, pp. 549-552

Abstract

Comparative genomic hybridization was applied for a comprehensive screening of frequently occurring net gains and losses of chromosomal subregions insmall populations of CD30(+) Hodgkin cells and their morphological variants. In 12 Hodgkin's lymphomas, recurrent gains were detected on chromosomal arms 2p, 9p, and 12q (in six, four, and five tumors, respectively) and distinct high-level amplifications were identified on chromosomal bands 4p16, 4q23-q24, and 9p23-p24. In Hodgkin cells with 9p23-p24 amplification, fluorescence ill situ hybridization revealed an increased copy number of chromosomal sequences spanning the tyrosine kinase gene JAK2, Several of the imbalances described, in particular a gain in chromosomal arm 9p that includes JAK2 amplification, are similar to the genomic changes detected in primary mediastinal B-cell lymphoma.

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Documento generato il 23/09/20 alle ore 11:30:42