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Titolo:
Epidemiology of drug exposure and adverse drug reactions in two Swiss departments of internal medicine
Autore:
Fattinger, K; Roos, M; Vergeres, P; Holenstein, C; Kind, B; Masche, U; Stocker, DN; Braunschweig, S; Kullak-Ublick, GA; Galeazzi, RL; Follath, F; Gasser, T; Meier, PJ;
Indirizzi:
Univ Zurich Hosp, Dept Internal Med, Div Clin Pharmacol & Toxicol, Zurich,Switzerland Univ Zurich Hosp Zurich Switzerland macol & Toxicol, Zurich,Switzerland Univ Zurich, ISPM, CH-8006 Zurich, Switzerland Univ Zurich Zurich Switzerland CH-8006 ISPM, CH-8006 Zurich, Switzerland Univ Zurich Hosp, Fdn Drug Safety & Comprehens Hosp Drug Monitoring, Zurich, Switzerland Univ Zurich Hosp Zurich Switzerland rug Monitoring, Zurich, Switzerland Kantonsspital, Dept Internal Med, St Gallen, Switzerland Kantonsspital StGallen Switzerland nternal Med, St Gallen, Switzerland Univ Zurich Hosp, Dept Internal Med, Zurich, Switzerland Univ Zurich HospZurich Switzerland t Internal Med, Zurich, Switzerland
Titolo Testata:
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
fascicolo: 2, volume: 49, anno: 2000,
pagine: 158 - 167
SICI:
0306-5251(200002)49:2<158:EODEAA>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
HOSPITAL ADMISSIONS;
Keywords:
adverse drug reactions; event monitoring; hospital pharmacoepidemiology; inpatients; medication usage;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Fattinger, K Univ Zurich Hosp, Dept Med, Div Clin Pharmacol & Toxicol, Ramistr 100, CH-8091 Zurich, Switzerland Univ Zurich Hosp Ramistr 100 Zurich Switzerland CH-8091 land
Citazione:
K. Fattinger et al., "Epidemiology of drug exposure and adverse drug reactions in two Swiss departments of internal medicine", BR J CL PH, 49(2), 2000, pp. 158-167

Abstract

Aims To explore drug exposure, frequency of adverse drug reactions (ADRs),types of ADRs, predisposing risk factors and ADR-related excess hospital stay in medical inpatients. Methods Structured data regarding patient characteristics, 'events' (symptoms, laboratory results), diagnoses (ICD10) and drug therapy were collectedusing a computer-supported data entry system and an interface for data retrieval from electronic patient records. ADR data were collected by 'event monitoring' to minimize possible bias by the drug monitor. The causality of each event was assessed in relation to disease(s) and drug therapy. Results The analysis included 4331 (100%) hospitalizations. The median observation period was 8 days. The median number of different drugs administered per patient and day was 6 and varied between 4 (Q(1)) and 9 (Q(3)) different drugs in 50% of all hospital days. In 41% of all hospitalizations at least one disease-unrelated event could be possibly attributed to drug therapy. Clinically relevant ADRs occurred in 11% of all hospitalizations. In 3.3% of all hospitalizations ADRs were the cause of hospital admission. The incidence of possibly ADR-related deaths was 1.4 parts per thousand. Factorspredisposing for clinically relevant ADRs were female gender and polypharmacy. ADR-related excess hospital stay accounted for 8.6% of hospital days. Conclusions These data demonstrate the feasibility of the developed 'eventmonitoring' system for quantitative analysis of ADRs in medical inpatients. With increasing numbers of recorded patients the pharmacoepidemiological database provides a valuable tool to study specific questions regarding drugs efficacy and safety in hospitalized patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/20 alle ore 21:57:46