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Titolo:
Relationship of vascular maturation in breast cancer blood vessels to vascular density and metastasis, assessed by expression of a novel basement membrane component, LH39
Autore:
Kakolyris, S; Fox, SB; Koukourakis, M; Giatromanolaki, A; Brown, N; Leek, RD; Taylor, M; Leigh, IM; Gatter, KC; Harris, AL;
Indirizzi:
Univ Oxford, John Radcliffe Hosp, Imperial Canc Res Fund, Oncol Mol Lab, Oxford OX3 9DU, England Univ Oxford Oxford England OX3 9DU ncol Mol Lab, Oxford OX3 9DU, England Univ Oxford, John Radcliffe Hosp, Dept Cellular Sci, Oxford OX3 9DU, England Univ Oxford Oxford England OX3 9DU Cellular Sci, Oxford OX3 9DU, England Churchill Hosp, Imperial Canc Res Fund, Clin Oncol Unit, Oxford OX3 7LJ, England Churchill Hosp Oxford England OX3 7LJ ncol Unit, Oxford OX3 7LJ, England Royal London Hosp, Expt Dermatol Lab, London E1 1BB, England Royal London Hosp London England E1 1BB atol Lab, London E1 1BB, England Univ Hosp Heraklion, Dept Clin Oncol, Heraklion 71110, Crete, Greece Univ Hosp Heraklion Heraklion Crete Greece 71110 ion 71110, Crete, Greece Univ Hosp Heraklion, Canc Biol Lab, Heraklion 71110, Crete, Greece Univ Hosp Heraklion Heraklion Crete Greece 71110 ion 71110, Crete, Greece Christchurch Hosp, Christchurch, New Zealand Christchurch Hosp Christchurch New Zealand p, Christchurch, New Zealand
Titolo Testata:
BRITISH JOURNAL OF CANCER
fascicolo: 4, volume: 82, anno: 2000,
pagine: 844 - 851
SICI:
0007-0920(200002)82:4<844:ROVMIB>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
ADHESION MOLECULE EXPRESSION; TUMOR-RELATED ANGIOGENESIS; ENDOTHELIAL-CELL GROWTH; PROGNOSTIC VALUE; P-SELECTIN; INHIBITION; CARCINOMA; PEPTIDE; PROLIFERATION; MELANOMA;
Keywords:
LH39; angiogenesis; vascular maturation; breast cancer;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Harris, AL Univ Oxford, John Radcliffe Hosp, Imperial Canc Res Fund, OncolMol Lab, Oxford OX3 9DU, England Univ Oxford Oxford England OX3 9DU b, Oxford OX3 9DU, England
Citazione:
S. Kakolyris et al., "Relationship of vascular maturation in breast cancer blood vessels to vascular density and metastasis, assessed by expression of a novel basement membrane component, LH39", BR J CANC, 82(4), 2000, pp. 844-851

Abstract

Angiogenesis, the formation of new vessels, has been demonstrated to be anindicator of prognosis in breast cancer patients. The extent of differentiation of the tumour vessels may affect access of peripheral white cells andegress or invasion of tumour cells. This has not been assessed in relationto tumour microvessel density or other variables and may be a marker of vascular remodelling. LH39 is a monoclonal antibody recognizing an epitope located at the lamina lucida of mature small veins and capillaries but not innewly formed vessels. To study vascular differentiation in breast tumours,we examined the vascular maturation index (VMI) in 12 normal and 50 breastcarcinomas and this was correlated with different clinicopathological variables including angiogenesis. Mature vessels were defined by staining with antibodies to both LH39 and to CD31, using double immunohistochemistry, whereas immature vessels stained only for CD31. VMI was defined as the % fraction of mature vessels (LH39-positive) / total number of vessels (CD31-positive). The VMI was significantly higher in normal (54-68.5%; median 66.5%) than in tumours (0-47%; median 8.8%) (P = 0.0005), There was a significant inverse correlation between the tumour VMI and nodal status (Fishers exact test, P = 0.01) and between high VMI and low thymidine phosphorylase (TP) expression (Mann-Whitney U-test, P = 0.01). No significant association between VMI and tumour size, oestrogen receptor, epidermal growth factor receptor, grade, angiogenesis, patient age, or E-selectin was seen. There was a significant reduction in relapse-free survival (P = 0.01) with high angiogenesis. These findings show that the VMI gives new information on the mechanismof tumour angiogenesis independently from microvessel quantitation, there is a wide variation in the differentiation of tumour vasculature but the degree of capillary differentiation is not associated with quantitative angiogenesis. The VMI identifies a subset of patients who have a high chance of regional node involvement. (C) 2000 Cancer Research Campaign.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/10/20 alle ore 16:14:53