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Titolo:
Anti-A isoagglutinin as a risk factor for the development of pure red cellaplasia after major ABO-incompatible allogeneic bone marrow transplantation
Autore:
Lee, JH; Lee, KH; Kim, S; Lee, JS; Kim, SH; Kwon, SW; Kim, WK;
Indirizzi:
Univ Ulsan, Dept Med, Div Hematol Oncol, Asan Med Ctr,Songpa Ku, Seoul 138040, South Korea Univ Ulsan Seoul South Korea 138040 Songpa Ku, Seoul 138040, South Korea Univ Ulsan, Asan Med Ctr, Dept Clin Pathol, Seoul, South Korea Univ UlsanSeoul South Korea Ctr, Dept Clin Pathol, Seoul, South Korea
Titolo Testata:
BONE MARROW TRANSPLANTATION
fascicolo: 2, volume: 25, anno: 2000,
pagine: 179 - 184
SICI:
0268-3369(200001)25:2<179:AIAARF>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
DONOR-TYPE; ERYTHROPOIETIN; TRANSFUSION; RECIPIENT; ANEMIA;
Keywords:
anti-A isoagglutinin; PRCA; ABO-incompatible BMT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Lee, JH Univ Ulsan, Dept Med, Div Hematol Oncol, Asan Med Ctr,Songpa Ku, 388-1 Poongnap Dong, Seoul 138040, South Korea Univ Ulsan 388-1 Poongnap Dong Seoul South Korea 138040 uth Korea
Citazione:
J.H. Lee et al., "Anti-A isoagglutinin as a risk factor for the development of pure red cellaplasia after major ABO-incompatible allogeneic bone marrow transplantation", BONE MAR TR, 25(2), 2000, pp. 179-184

Abstract

Delayed erythropoiesis and pure red cell aplasia (PRCA) have been reportedafter major ABO-incompatible BMT. We attempted to find risk factors for the development of PRCA in 27 patients who underwent major ABO-incompatible BMT, In all patients, the donor marrow was depleted of RBCs before infusion. In 22 patients, isoagglutinins were determined until they disappeared. In eight (29.6%) out of 27 patients, bone marrow examination following BMT showed the findings of PRCA, We analyzed various clinico-pathologic risk factors and isoagglutinin type was the only significant risk factor. Patients with anti-A isoagglutinins against donor RBC developed PRCA more frequently than patients with anti-B (8/17 vs 0/9), Median days to the disappearance ofisoagglutinins tended to be longer in patients with PRCA (PRCA vs non-PRCA, 200 vs 66 days) and in cases with anti-A isoagglutinins (anti-A vs anti-B, 160 vs 51 days). Times to disappearance of isoagglutinins correlated withtimes to reticulocytes over 1% and initial appearance of donor type RBC (R-2 = 0.708 and 0.711), In conclusion, RBC engraftment following major ABO-incompatible BMT was dependent on the disappearance of isoagglutinins against donor RBC, and anti-A isoagglutinin was a risk factor for the developmentof PRCA after major ABO-incompatible allogeneic BMT.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/09/20 alle ore 10:59:06