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Titolo:
Alterations in serum and brain trace element levels after antidepressant treatment. Part II. Copper
Autore:
Schlegel-Zawadzka, M; Nowak, G;
Indirizzi:
Jagiellonian Univ, Coll Med, Dept Food Chem & Nutr, PL-30688 Krakow, Poland Jagiellonian Univ Krakow Poland PL-30688 & Nutr, PL-30688 Krakow, Poland Jagiellonian Univ, Coll Med, Lab Radioligand Res, PL-30688 Krakow, Poland Jagiellonian Univ Krakow Poland PL-30688 nd Res, PL-30688 Krakow, Poland Polish Acad Sci, Inst Pharmacol, PL-31343 Krakow, Poland Polish Acad Sci Krakow Poland PL-31343 harmacol, PL-31343 Krakow, Poland
Titolo Testata:
BIOLOGICAL TRACE ELEMENT RESEARCH
fascicolo: 1, volume: 73, anno: 2000,
pagine: 37 - 45
SICI:
0163-4984(200001)73:1<37:AISABT>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALZHEIMERS-DISEASE; DEPRESSION; RATS; ZINC; CERULOPLASMIN; REGIONS; ILLNESS; IRON;
Keywords:
antidepressant drugs; ECS; copper level; brain; serum; rats;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Schlegel-Zawadzka, M Jagiellonian Univ, Coll Med, Dept Food Chem & Nutr, Medyczna 9, PL-30688 Krakow, Poland Jagiellonian Univ Medyczna 9 Krakow Poland PL-30688
Citazione:
M. Schlegel-Zawadzka e G. Nowak, "Alterations in serum and brain trace element levels after antidepressant treatment. Part II. Copper", BIOL TR EL, 73(1), 2000, pp. 37-45

Abstract

We have studied the effect of chronic treatment with imipramine, citalopram, and electroconvulsive shock (ECS) on serum and brain copper levels in rats. Chronic treatment with citalopram and imipramine (but not ECS) significantly (approx 14%) decreased the serum copper level. Chronic treatment withboth drugs did not alter the brain copper level. However, chronic ECS induced a significant increase (by 36%) in the copper level in the hippocampus and also in the cerebellum (by 16%). Ln contrast to the zinc, where both pharmacologic and ECS treatment increased its hippocampal concentration, these two antidepressant therapy (drugs versus ECS) differ in their effect on brain copper level. These findings suggest that the mechanism by which copper is involved in ECS differs from that of any involvement in the action of the drugs studied.

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Documento generato il 03/04/20 alle ore 07:02:06