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Titolo:
Studying metabolic regulation in human muscle
Autore:
Kemp, GJ;
Indirizzi:
Univ Liverpool, Dept Musculoskeletal Sci, Liverpool L69 3GA, Merseyside, England Univ Liverpool Liverpool Merseyside England L69 3GA , Merseyside, England
Titolo Testata:
BIOCHEMICAL SOCIETY TRANSACTIONS
, volume: 28, anno: 2000,
parte:, 2
pagine: 100 - 103
SICI:
0300-5127(200002)28:<100:SMRIHM>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN SKELETAL-MUSCLE; MAGNETIC-RESONANCE SPECTROSCOPY; OXIDATIVE-PHOSPHORYLATION; CREATINE-KINASE; P-31 NMR; OXYGEN-CONSUMPTION; ATP HYDROLYSIS; MITOCHONDRIAL; RECOVERY; EXERCISE;
Keywords:
ATP turnover; mitochondria; oxidative phosphorylation; P-31 magnetic resonance spectroscopy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Kemp, GJ Univ Liverpool, Dept Musculoskeletal Sci, Liverpool L69 3GA, Merseyside, England Univ Liverpool Liverpool Merseyside England L69 3GA ide, England
Citazione:
G.J. Kemp, "Studying metabolic regulation in human muscle", BIOCH SOC T, 28, 2000, pp. 100-103

Abstract

Phosphorus magnetic resonance spectroscopy, despite some limitations, is avaluable non-invasive window on muscle metabolism in vivo, particularly oxidative ATP synthesis. A number of experiments have shown this to be dominated by closed-loop feedback mechanisms: a well-known model posits regulation by ADP, but there are others, difficult to distinguish experimentally. Moreover the contribution of open-loop control mechanisms ('feed forward' or 'parallel activation') in vivo remains controversial. Progress will requiremore precise data, better integrated with other measurements (e.g. muscle oxygenation), and improvement of the conceptual tools appropriate to such studies, where data are limited and steady-state assumptions frequently inapplicable.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 07:32:20