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Titolo:
Use of a delayed non-matching to position task to model age-dependent cognitive decline in the dog
Autore:
Adams, B; Chan, A; Callahan, H; Siwak, C; Tapp, D; Ikeda-Douglas, C; Atkinson, P; Head, E; Cotman, CW; Milgram, NW;
Indirizzi:
Univ Toronto, Div Life Sci, Scarborough, ON M1C 1A4, Canada Univ Toronto Scarborough ON Canada M1C 1A4 carborough, ON M1C 1A4, Canada Univ Calif Irvine, Inst Brain Aging & Dementia, Irvine, CA 92717 USA Univ Calif Irvine Irvine CA USA 92717 ng & Dementia, Irvine, CA 92717 USA Univ Toronto, Dept Physiol, Toronto, ON M5S 1AH, Canada Univ Toronto Toronto ON Canada M5S 1AH ysiol, Toronto, ON M5S 1AH, Canada Univ Toronto, Inst Med Sci, Toronto, ON M5S 1A8, Canada Univ Toronto Toronto ON Canada M5S 1A8 d Sci, Toronto, ON M5S 1A8, Canada Univ Toronto, Dept Pharmacol, Toronto, ON M5S 1AH, Canada Univ Toronto Toronto ON Canada M5S 1AH macol, Toronto, ON M5S 1AH, Canada
Titolo Testata:
BEHAVIOURAL BRAIN RESEARCH
fascicolo: 1, volume: 108, anno: 2000,
pagine: 47 - 56
SICI:
0166-4328(200002)108:1<47:UOADNT>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
SPATIAL WORKING-MEMORY; BETA-AMYLOID ACCUMULATION; HUMAN FRONTAL-CORTEX; RECOGNITION MEMORY; RHESUS-MONKEY; DEFICITS; PERFORMANCE; RATS; DYSFUNCTION; INFORMATION;
Keywords:
dog; spatial; memory; canine; cognition; aging; delayed non-matching to position;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Milgram, NW Univ Toronto, Div Life Sci, 1265 Mil Trail, Scarborough, ON M1C 1A4, Canada Univ Toronto 1265 Mil Trail Scarborough ON Canada M1C 1A4 nada
Citazione:
B. Adams et al., "Use of a delayed non-matching to position task to model age-dependent cognitive decline in the dog", BEH BRA RES, 108(1), 2000, pp. 47-56

Abstract

Spatial learning and memory in young and old dogs was studied in a series of experiments using a delayed non-matching to position (DNMP) paradigm. Past research from our laboratory has suggested that aged dogs perform more poorly on a version of the DNMP task compared to young dogs [Head et al., Spatial learning and memory as a function of age in the dog, Behav. Neurosci.1995;109(5):851-585]. We have now extended these findings by testing a large number of dogs on three different variations of the DNMP paradigm to evaluate different aspects of spatial learning and memory. Our results indicate that: (1) aged dogs show impaired spatial learning compared to young dogs, (2) aged dogs display spatial working memory deficits compared to young dogs, (3) young dogs have a greater maximum working spatial memory capacity than old dogs and (4) we can use the DNMP paradigm to cognitively categorize different subsets of aged dogs. These data indicate that the DNMP paradigm can serve as a valuable tool to evaluate age-dependent cognitive dysfunction in the canine. (C) 2000 Elsevier Science B.V. All rights reserved.

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Documento generato il 07/08/20 alle ore 07:00:05