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Titolo:
HPV33 DNA in premalignant and malignant breast lesions in Chinese and Japanese populations
Autore:
Yu, YY; Morimoto, T; Sasa, M; Okazaki, K; Harada, Y; Fujiwara, T; Irie, Y; Takahashi, EI; Tanigami, A; Izumi, K;
Indirizzi:
Univ Tokushima, Sch Med Sci, Tokushima 7708509, Japan Univ Tokushima Tokushima Japan 7708509 Med Sci, Tokushima 7708509, Japan Shanghai First Peoples Hosp, Dept Pathol, Shanghai 200080, Peoples R ChinaShanghai First Peoples Hosp Shanghai Peoples R China 200080 ples R China Tokushima Breast Care Clin, Tokushima 7700052, Japan Tokushima Breast CareClin Tokushima Japan 7700052 ushima 7700052, Japan Kunitomi Surg Clin Okayama, Okayama 7038236, Japan Kunitomi Surg Clin Okayama Okayama Japan 7038236 Okayama 7038236, Japan Otsuka Pharmaceut Co Ltd, Otsuka GEN Res Inst, Tokushima 7710192, Japan Otsuka Pharmaceut Co Ltd Tokushima Japan 7710192 okushima 7710192, Japan Univ Tokushima, Sch Med, Dept Pathol 2, Tokushima 7708503, Japan Univ Tokushima Tokushima Japan 7708503 athol 2, Tokushima 7708503, Japan
Titolo Testata:
ANTICANCER RESEARCH
fascicolo: 6B, volume: 19, anno: 1999,
pagine: 5057 - 5061
SICI:
0250-7005(199911/12)19:6B<5057:HDIPAM>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN PAPILLOMAVIRUS; CANCER; CARCINOMA; ABSENCE; HPV-16;
Keywords:
HPV; PCR; Southern blot hybridization; breast cancer; mammary lesions;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
14
Recensione:
Indirizzi per estratti:
Indirizzo: Morimoto, T Univ Tokushima, Sch Med Sci, 3-18-15 Kuramoto Cho, Tokushima 7708509, Japan Univ Tokushima 3-18-15 Kuramoto Cho Tokushima Japan 7708509 n
Citazione:
Y.Y. Yu et al., "HPV33 DNA in premalignant and malignant breast lesions in Chinese and Japanese populations", ANTICANC R, 19(6B), 1999, pp. 5057-5061

Abstract

The relationship between human papillomavirus (HPV) infection and breast cancel is controversial. In this study, paraffin-embedded tissue blocks prepared from 72 patients with benign, premalignant or malignant mammary lesions were randomly collected from the Shanghai region of China and Tokushima in Japan. DNA specimens extracted from all tissues were amplified by the polymerase chain reaction (PCR) using HPV16, IS and 33 primers. Southern blot hybridization showed 19 cases to be positive for HPV33 DNA: The positive rate for HPV33 DNA in Chinese (41.7%) was significantly higher than in Japanese (11.1%) (P < 0.01): The positive rate for. HPV33 DNA in invasive ductal carcinoma (34.1%) was higher than in benign or borderline mammary lesions (5%) (P < 0.02). There were no statistically significant difference among the relationship of the nuclear grade of breast cancels with HPV33 DNA-positivity. This is the first report of a positive correlation between HPV33 DNA and breast lesions in Chinese and Japanese populations. These results suggest that the infection by HPV33, but notHPV 16 or HPV 18, may be involved inbreast hyperplastic lesions, especially breast cancel, in humans.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 12:29:59