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Titolo:
Effects of interferon-gamma on secretion of vascular endothelial growth factor by endometrial stromal cells
Autore:
Kawano, Y; Matsui, N; Kamihigashi, S; Narahara, H; Miyakawa, I;
Indirizzi:
Oita Med Univ, Dept Obstet & Gynecol, Oita 8795593, Japan Oita Med Univ Oita Japan 8795593 t Obstet & Gynecol, Oita 8795593, Japan
Titolo Testata:
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
fascicolo: 1, volume: 43, anno: 2000,
pagine: 47 - 52
SICI:
1046-7408(200001)43:1<47:EOIOSO>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
SMOOTH-MUSCLE CELLS; TYROSINE KINASE; FACTOR EXPRESSION; EPITHELIAL-CELLS; GENE-EXPRESSION; RECEPTOR; ANGIOGENESIS; INVITRO; IDENTIFICATION; LOCALIZATION;
Keywords:
endometrial stromal cells; interferon-gamma; vascular endothelial growth factor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Kawano, Y Oita Med Univ, Dept Obstet & Gynecol, 1-1 Idaigaoka, Oita 8795593, Japan Oita Med Univ 1-1 Idaigaoka Oita Japan 8795593 a 8795593, Japan
Citazione:
Y. Kawano et al., "Effects of interferon-gamma on secretion of vascular endothelial growth factor by endometrial stromal cells", AM J REPROD, 43(1), 2000, pp. 47-52

Abstract

PROBLEM: The aim of this study was to clarify the physiological effects ofinterferon (IFN)-gamma on secretion of vascular endothelial growth factor (VEGF) by endometrial stromal (ES) cells. METHOD OF STUDY: ES cells were obtained from human uterine endometrium by enzymic digestion and filtration. The effects of IFN-gamma on production ofVEGF by ES cells were examined by analyzing VEGF mRNA expression with Northern blotting analysis and by assaying VEGF protein. RESULTS: IFN-gamma inhibited VEGF mRNA and protein expression by ES cells in a dose-dependent manner. In ES cells treated with IFN-gamma, VEGF production was not significant until 6 hr of incubation and was significantly affected after 6 hr of incubation, but decreased significantly after 12 to 48 hr. IFN-gamma also suppressed VEGF mRNA expression by ES cells. CONCLUSIONS: ES cells produce VEGF, which may contribute to endometrial neovascularization and proliferation. IFN-gamma may play an important role inregulating VEGF production by ES cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 05:32:31