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Titolo:
Prednisone and aspirin improve pregnancy rate in patients with reproductive failure and autoimmune antibodies: A prospective study
Autore:
Geva, E; Amit, A; Lerner-Geva, L; Yaron, Y; Daniel, Y; Schwartz, T; Azem, F; Yovel, I; Lessing, JB;
Indirizzi:
Lis Matern Hosp, Tel Aviv Sourasky Med Ctr, Sara Racine In Vitro Fertilizat, Tel Aviv, Israel Lis Matern Hosp Tel Aviv Israel e In Vitro Fertilizat, Tel Aviv, Israel Tel Aviv Univ, Sackler Fac Med, IL-69978 Tel Aviv, Israel Tel Aviv Univ Tel Aviv Israel IL-69978 ac Med, IL-69978 Tel Aviv, Israel
Titolo Testata:
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
fascicolo: 1, volume: 43, anno: 2000,
pagine: 36 - 40
SICI:
1046-7408(200001)43:1<36:PAAIPR>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
IN-VITRO FERTILIZATION; LOW-DOSE ASPIRIN; ANTIPHOSPHOLIPID ANTIBODIES; ANTICARDIOLIPIN ANTIBODIES; RECURRENT MISCARRIAGE; EMBRYO-TRANSFER; UNEXPLAINED INFERTILITY; IMPLANTATION FAILURE; LUPUS ANTICOAGULANT; SEROPOSITIVE WOMEN;
Keywords:
anti-cardiolipin; autoantibodies; autoimmunity; IVF failure; pregnancy rate;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Geva, E Univ Calif San Francisco, Ctr Reprod Sci, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 CA 94143 USA
Citazione:
E. Geva et al., "Prednisone and aspirin improve pregnancy rate in patients with reproductive failure and autoimmune antibodies: A prospective study", AM J REPROD, 43(1), 2000, pp. 36-40

Abstract

PROBLEM: The study was conducted to investigate the efficacy of prednisoneand aspirin in autoantibody seropositive patients with repeated in vitro fertilization-embryo transfer (IVF-ET) failure,METhODS OF STUDY: The study group comprised 52 consecutive patients seropositive for non-organ-specific autoantibodies? i.e., anti-cardiolipin antibodies (ACA), anti-nuclear antibodies (ANA). anti-double-stranded (ds) DNA, rheumatoid factor (RF), and lupus anti-coagulant (LAC). These patients were treated with prednisone, 10 mg per day, and aspirin, 100 mg per day, starting 4 weeks before induction of ovulation in 52 IVF cycles. RESULTS: The clinical pregnancy rate per cycle was 32.7% (17/52). No increased incidence of pregnancy complications. including premature labor, gestational diabetes mellitus, and pregnancy-induced of hypertension, were found. CONCLUSIONS: Combined treatment of prednisone for immunosupression and aspirin as an anti-thrombotic agent, starting before ovulation induction, may improve pregnancy rate in autoantibody seropositive patients who have had repeated IVF-ET failures.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 01:59:01