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Titolo:
No cyclicity in serum vascular endothelial growth factor during normal menstrual cycle but significant luteal phase elevation during an in vitro fertilization program
Autore:
Unkila-Kallio, L; Vuorela-Vepsalainen, P; Tiitinen, A; Halmesmaki, E; Ylikorkala, O;
Indirizzi:
CHU Helsinki, Dept Obstet & Gynecol, Helsinki 00290, Finland CHU HelsinkiHelsinki Finland 00290 t & Gynecol, Helsinki 00290, Finland
Titolo Testata:
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
fascicolo: 1, volume: 43, anno: 2000,
pagine: 25 - 30
SICI:
1046-7408(200001)43:1<25:NCISVE>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
OVARIAN HYPERSTIMULATION SYNDROME; HUMAN CHORIONIC-GONADOTROPIN; LUTEINIZED GRANULOSA-CELLS; PERMEABILITY FACTOR; IN-VITRO; HUMAN PLACENTA; BREAST-CANCER; VEGF-C; EXPRESSION; WOMEN;
Keywords:
BMI; infertility; IVF; pregnancy; progesterone; VEGF;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Ylikorkala, O CHU Helsinki, Dept Obstet & Gynecol, POB 140, Helsinki 00290, Finland CHU Helsinki POB 140 Helsinki Finland 00290 00290, Finland
Citazione:
L. Unkila-Kallio et al., "No cyclicity in serum vascular endothelial growth factor during normal menstrual cycle but significant luteal phase elevation during an in vitro fertilization program", AM J REPROD, 43(1), 2000, pp. 25-30

Abstract

PROBLEM: To compare changes in serum Vascular endothelial growth factor (VEGF) levers during normal and in vitro fertilization (IVF) cycles. METHOD OF STUDY: Ten healthy women with ovulatory cycles and 37 infertile women participating in an IVF program were followed by frequent serum samples and with VEGF measurements throughout their cycles. RESULTS: Serum VEGF remained unchanged during the normal menstrual cycle, whereas the IVF program participants showed elevations in serum VEGF in theluteal phase of the cycle. When data from controls and patients were pooled, redundant midluteal VEGF level correlated with progesterone and with peak follicular phase estrogen level. The midluteal VEGF level in the IVF cycles was associated with body mass index (P < 0.01) and progesterone level (P< 0.05) by multiple regression. The 14 women conceiving tended to have higher VEGF levels than those failing to become pregnant. CONCLUSIONS: The IVF program was associated with increased synthesis of VEGF either in the ovaries, endometrium, or at other sites and this may be ofsignificance for the outcome of IVF.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 21:19:48