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Titolo:
The influence of different types of antibodies on in vitro fertilization results
Autore:
Mardesic, T; Ulcova-Gallova, Z; Huttelova, R; Muller, P; Voboril, J; Mikova, M; Hulvert, J;
Indirizzi:
Inst Pronatal, Prague 14700 4, Czech Republic Inst Pronatal Prague CzechRepublic 14700 4 ague 14700 4, Czech Republic Charles Univ, Dept Obstet & Gynecol, Pilsen 11636 1, Czech Republic Charles Univ Pilsen Czech Republic 11636 1 ilsen 11636 1, Czech Republic
Titolo Testata:
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
fascicolo: 1, volume: 43, anno: 2000,
pagine: 1 - 5
SICI:
1046-7408(200001)43:1<1:TIODTO>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
SPERM-IMMOBILIZING ANTIBODIES; ANTISPERM ANTIBODIES; ZONA-PELLUCIDA; ANTIPHOSPHOLIPID ANTIBODIES; INTRAUTERINE INSEMINATION; INFERTILE WOMEN; CERVICAL-MUCUS; SPERMATOZOA; INVITRO; AUTOANTIBODIES;
Keywords:
autoantibodies; autoimmunity; ICSI; IVF; pregnancy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Mardesic, T Inst Pronatal, Na Dioube Mexi 4, Prague 14700 4, Czech Republic Inst Pronatal Na Dioube Mexi 4 Prague Czech Republic 14700 4
Citazione:
T. Mardesic et al., "The influence of different types of antibodies on in vitro fertilization results", AM J REPROD, 43(1), 2000, pp. 1-5

Abstract

PROBLEM: The influence of anti-sperm (ASA), anti-phospholipid (APA), and anti-zonal (AZA) antibodies on in vitro fertilization (IVF) results and the need for intracytoplasmic sperm injection (ICSI) were assessed. METHOD OF STUDY: Forty-four couples with infertility of immunologic originwere investigated. ASA in serum and ovulatory mucus were studied by a trayagglutination test (TAT) and indirect mixed anti-globulin reaction test (MAR) test, AZA were studied by passive hemagglutination and commercial enzyme-linked immunosorbent assay (ELISA; BioGen, Germany), and APA were tested by ELISAs in immunoglobulin isotypes IgG and IgM. RESULTS: Because of failed or very low fertilization after standard NF in the previous cycle. ICSI had to be used in five out of 15 cases with ASA (33.3%), in 16 out of Is couples with AZA (89.4%), and in only one case if APA were present (9%). Clinical pregnancy rate was 60% in cases with ASA, 38.5% with AZA, and 27.3% per embryo transfer (ET) if APA were detected. CONCLUSIONS: Immunologic infertility can be treated by IVF with very good results. The most important group are women with AZA, in whom IVF-ICSI without any delay is recommended.

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Documento generato il 25/11/20 alle ore 15:10:58