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Titolo:
Metabolic control of food intake and estrous cycles in Syrian hamsters. I.Plasma insulin and leptin
Autore:
Schneider, JE; Blum, RM; Wade, GN;
Indirizzi:
Lehigh Univ, Dept Biol Sci, Bethlehem, PA 18015 USA Lehigh Univ BethlehemPA USA 18015 Dept Biol Sci, Bethlehem, PA 18015 USA Univ Massachusetts, Dept Psychol, Ctr Neuroendocrine Studies, Amherst, MA 01003 USA Univ Massachusetts Amherst MA USA 01003 ne Studies, Amherst, MA 01003 USA
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
fascicolo: 2, volume: 278, anno: 2000,
pagine: R476 - R485
SICI:
0363-6119(200002)278:2<R476:MCOFIA>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
LUTEINIZING-HORMONE SECRETION; FATTY-ACID OXIDATION; OB GENE-EXPRESSION; BODY-WEIGHT; ADIPOSE-TISSUE; OBESE GENE; GONADOTROPIN-SECRETION; ENERGY-BALANCE; FEMALE RATS; EARLY-ONSET;
Keywords:
fasting; ob protein; refeeding; sex behavior;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
70
Recensione:
Indirizzi per estratti:
Indirizzo: Schneider, JE Lehigh Univ, Dept Biol Sci, 111 Res Dr, Bethlehem, PA 18015 USA Lehigh Univ 111 Res Dr Bethlehem PA USA 18015 , PA 18015 USA
Citazione:
J.E. Schneider et al., "Metabolic control of food intake and estrous cycles in Syrian hamsters. I.Plasma insulin and leptin", AM J P-REG, 278(2), 2000, pp. R476-R485

Abstract

The "adipostat hypothesis" refers to the idea that circulating hormone concentrations reflect levels of body adiposity and act as signals to control food intake and reproduction. Implicit in the adipostatic hypothesis are the following two assumptions: 1) plasma levels of adipostatic hormones accurately reflect body fat content and 2) decreased plasma concentrations of adipostatic hormones necessarily result in increased food intake and inhibited reproductive processes. The present experiments are designed to test these assumptions. Fat and lean Syrian hamsters were either fasted for 12, 24, 36, or 48 h or allowed ad libitum access to food. Contrary to the first assumption, plasma leptin and insulin levels in fat hamsters dropped dramatically by 12 h after the start of a fast, with no significant change in body fat content and no postfast hyperphagia. Lean hamsters showed anestrus aftera 48-h fast but not after a 24-h fast. Contrary to the second assumption of the lipostatic hypothesis, lean hamsters fasted for 24 h and then refed for the next 24 h had leptin levels that were not significantly elevated compared with those of 48-h-fasted hamsters. Thus, in adult female Syrian hamsters, plasma leptin concentrations do not accurately reflect body fat content under all conditions; normal estrous cyclicity does not necessarily require plasma leptin concentrations higher than those of fasted hamsters; and decreased plasma leptin levels do not result in increased food intake.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 05:09:40