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Titolo:
Developmental changes of cardiac function and mass assessed with MRI in neonatal, juvenile, and adult mice
Autore:
Wiesmann, F; Ruff, J; Hiller, KH; Rommel, E; Haase, A; Neubauer, S;
Indirizzi:
Univ Wurzburg, Med Klin, Dept Cardiol, D-97080 Wurzburg, Germany Univ Wurzburg Wurzburg Germany D-97080 ardiol, D-97080 Wurzburg, Germany Univ Wurzburg, Inst Biophys, D-97080 Wurzburg, Germany Univ Wurzburg Wurzburg Germany D-97080 iophys, D-97080 Wurzburg, Germany
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
fascicolo: 2, volume: 278, anno: 2000,
pagine: H652 - H657
SICI:
0363-6135(200002)278:2<H652:DCOCFA>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
IN-VIVO ASSESSMENT; MOUSE HEART;
Keywords:
magnetic resonance imaging; mouse heart; neonatal physiology; ventricular mass;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Wiesmann, F Univ Wurzburg, Med Klin, Dept Cardiol, Josef Schneider Str 2, D-97080 Wurzburg, Germany Univ Wurzburg Josef Schneider Str 2 Wurzburg Germany D-97080
Citazione:
F. Wiesmann et al., "Developmental changes of cardiac function and mass assessed with MRI in neonatal, juvenile, and adult mice", AM J P-HEAR, 278(2), 2000, pp. H652-H657

Abstract

Cardiovascular transgenic mouse models with an early phenotype or even premature death require noninvasive imaging methods that allow for accurate visualization of cardiac morphology and function. Thus the purpose of our study was to assess the feasibility of magnetic resonance imaging (MRI) to characterize cardiac function and mass in newborn, juvenile, and adult mice. Forty-five C57bl/6 mice from seven age groups (3 days to 4 mo after birth) were studied by MRI under isoflurane anesthesia. Electrocardiogram-gated cine MRI was performed with an in-plane resolution of (78-117 mu m)(2). Temporal resolution per cine frame was 8.6 ms. MRI revealed cardiac anatomy in mice from all age groups with high temporal and spatial resolution. There wasclose correlation between MRI-and autopsy-determined left ventricular (LV)mass (r = 0.95, SE of estimate = 9.5 mg). The increase of LV mass (range 9.6-101.3 mg), cardiac output (range 1.1-14.3 ml/min), and stroke volume (range 3.2-40.2 mu l) with age could be quantified by MRI measurements. Ejection fraction and cardiac index did not change with aging. However, LV mass index decreased with increasing age (P < 0.01). High-resolution MRI allows for accurate in vivo assessment of cardiac function in neonatal, juvenile, and adult mice. This method should be useful when applied in transgenic mouse models.

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Documento generato il 20/09/20 alle ore 07:14:07