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Titolo:
Biological phenotypes associated with individuals at high risk for developing alcohol-related disorders: Part 1
Autore:
Hill, SY;
Indirizzi:
Univ Pittsburgh, Med Ctr, Dept Psychiat, Pittsburgh, PA 15213 USA Univ Pittsburgh Pittsburgh PA USA 15213 sychiat, Pittsburgh, PA 15213 USA
Titolo Testata:
ADDICTION BIOLOGY
fascicolo: 1, volume: 5, anno: 2000,
pagine: 5 - 22
SICI:
1355-6215(200001)5:1<5:BPAWIA>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
EVENT-RELATED POTENTIALS; DOPAMINE-D2 RECEPTOR GENE; SEROTONIN TRANSPORTER GENE; QUANTITATIVE TRAIT LOCI; HIGH-DENSITY FAMILIES; PREFERRING AA RATS; EEG-ALPHA-ACTIVITY; D2 RECEPTOR; A1 ALLELE; NUCLEUS-ACCUMBENS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
154
Recensione:
Indirizzi per estratti:
Indirizzo: Hill, SY Univ Pittsburgh, Med Ctr, Dept Psychiat, 3811 OHara St, Pittsburgh, PA 15213 USA Univ Pittsburgh 3811 OHara St Pittsburgh PA USA 15213 A 15213 USA
Citazione:
S.Y. Hill, "Biological phenotypes associated with individuals at high risk for developing alcohol-related disorders: Part 1", ADDICT BIOL, 5(1), 2000, pp. 5-22

Abstract

This article reviews the results of studies concerning particular classes of biological phenotypes that may have relevance for alcohol dependence. Broadly defined, these classes include brain neurotransmitter systems and neuroelectric potentials. Evidence is presented concerning genotypic variationin alcoholics and high-risk relatives suggesting that the etiology of alcoholism and other addictive diseases is mediated in part through sub-optimalneurotransmitter functioning. Research opportunities are offered with respect to specific candidate genes that have been cloned from these neurotransmitter systems that could be most fully utilized in family-based genetic analyses. Additional evidence is offered, suggesting that characteristics of particular neuroelectric potentials (e.g. the amplitude of the P300 component of the event-related potential) may provide another dimension of potential markers that could be used to identify children at risk. Finally, methodological considerations specific to high risk studies are discussed. Among these are the need to include a plan for studying more severe cases of alcohol dependence that are relatively uncomplicated by other major psychiatricdisorders. Plans for long-term follow-up of children at highest risk for developing the disorder should also be included. Multiple domains of inquiryshould nor be viewed as "unfocused" but rather as an economical means for utilizing highly characterized samples of individuals meeting rigorous research criteria.

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Documento generato il 23/01/20 alle ore 12:55:02