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Titolo:
Effects of exogenous testosterone on isolated rabbit corpus cavernosum penis
Autore:
Yildirim, S; Utkan, T; Yildirim, K; Sarioglu, Y;
Indirizzi:
Kocaeli Univ, Fac Med, Dept Pharmacol, TR-41900 Kocaeli, Turkey Kocaeli Univ Kocaeli Turkey TR-41900 Pharmacol, TR-41900 Kocaeli, Turkey Cumhuriyet Univ, Fac Med, Dept Pharmacol, TR-58140 Sivas, Turkey Cumhuriyet Univ Sivas Turkey TR-58140 Pharmacol, TR-58140 Sivas, Turkey
Titolo Testata:
ACTA PHARMACOLOGICA SINICA
fascicolo: 2, volume: 21, anno: 2000,
pagine: 139 - 144
SICI:
0253-9756(200002)21:2<139:EOETOI>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
SMOOTH-MUSCLE; NITRIC-OXIDE; ERECTILE DYSFUNCTION; NORMAL MEN; CASTRATION; RELAXATION; ANDROGEN; RESPONSIVENESS; CONTRACTIONS; RECEPTORS;
Keywords:
testosterone; penis; electric stimulation; phenylephrine; nitroprusside; carbachol; guanethidine; atropine; N-G-nitroarginine methyl ester; potassium chloride;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Utkan, T Kocaeli Univ, Fac Med, Dept Pharmacol, TR-41900 Kocaeli, Turkey Kocaeli Univ Kocaeli Turkey TR-41900 , TR-41900 Kocaeli, Turkey
Citazione:
S. Yildirim et al., "Effects of exogenous testosterone on isolated rabbit corpus cavernosum penis", ACT PHAR SI, 21(2), 2000, pp. 139-144

Abstract

AIM: To study the effects of exogenous excess of testosterone on the constricting effect of phenylephrine and endothelium-dependent and -independent relaxing effects of different:agonists in the corpus cavernosum penis (CCP). METHODS: Specimens of the CCP were obtained from rabbits testosterone for1 and 2 months and untreated for 2 months after testosterone-treatment for2 months. Preparations were mounted between two parallel platinum electrodes in organ baths. Responses to phenylephrine, car bachol, and:sodium nitroprusside were obtained by adding the reagent cumulatively to the bath. RESULTS: The phenylephrine-induced contractions were decreased with no change in agonist potency (pD(2) value) after both 1 and 2 month testosterone-treatment and did not return to control: values in corpus cavernosum obtained from rabbits untreated for 2:months after testosterone-treatment for 2 months. Testosterone treatment for 1 or 2 months increased the endothelium-dependent relaxations induced by carbachol and decreased the relaxations elicitedby electric stimulation but did not affect the relaxations induced by sodium nitroprusside. These relaxant responses to carbachol and electric stimulation did not return to control values in corpus cavernosum obtained from rabbits untreated for 2 months after testosterone-treatment for 2 months. There were no significant changes in the pD(2) values calculated:by agonist-induced relaxation responses in all tesrosterone-treatment.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 10:16:27