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Titolo:
Papillary glioneuronal tumour: clinicopathological and biochemical study of one case with 7-year follow up
Autore:
Bouvier-Labit, C; Daniel, L; Dufour, H; Grisoli, F; Figarella-Branger, D;
Indirizzi:
Hop Enfants La Timone, Serv Anat Pathol & Neuropathol, F-13385 Marseille 05, France Hop Enfants La Timone Marseille France 05 , F-13385 Marseille 05, France Hop Enfants La Timone, Serv Neurochirurg, F-13385 Marseille, France Hop Enfants La Timone Marseille France F-13385 F-13385 Marseille, France
Titolo Testata:
ACTA NEUROPATHOLOGICA
fascicolo: 3, volume: 99, anno: 2000,
pagine: 321 - 326
SICI:
0001-6322(200003)99:3<321:PGTCAB>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL; NEUROCYTOMA; EXPRESSION; ISOFORMS;
Keywords:
papillary; glioneuronal tumour; electron microscopy; NCAM; L1 adhesion molecule;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
13
Recensione:
Indirizzi per estratti:
Indirizzo: Figarella-Branger, D Hop Enfants La Timone, Serv Anat Pathol & Neuropathol, Chemin Armee Afr, F-13385 Marseille 05, France Hop Enfants La Timone Chemin Armee Afr Marseille France 05
Citazione:
C. Bouvier-Labit et al., "Papillary glioneuronal tumour: clinicopathological and biochemical study of one case with 7-year follow up", ACT NEUROP, 99(3), 2000, pp. 321-326

Abstract

Among the mixed glioneuronal tumours, a new variant called papillary glioneuronal tumour has recently been delineated. A case occurring in a 23-year-old man is reported. The tumour was cystic with a mural nodule enhanced by gadolinium injection. It was located within the left parieto-occipital lobe, Surgical excision showed a greyish friable tumour with cystic areas. Histopathological examination revealed a pseudopapillary component comprising asingle layer of regular cells, arranged around hyalinised vessels. These cells were immunoreactive with anti-glial fibrillary acidic protein and HNK1antibodies. A neurocytoma-like component coexisted with round blind cells and focal fibrillary rosettes. These cells were immunostained by anti-neuron-specific enolase and anti-synaptophysin antibodies. Neither mitoses nor ganglioid cells were seen. HNK1, the three isoforms of NCAM, and the L1 adhesion molecule were detected by Western blot analysis. Ultrastructural studyshowed three different types of cells. The first contained gliofilaments, the second showed long processes with true synapses, and the third was poorly differentiated. However, all had identical nuclei and contained dense bodies. These findings suggest a common origin for the tumour cells derived from a bipotential neuroglial progenitor As for other mature mixed neuroglial rumours, the prognosis is good. Our patient is free of disease 7 years after complete surgical treatment.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 07:04:18