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Titolo:
Hepatitis C virus infection and myositis: a polymerase chain reaction study
Autore:
Villanova, M; Caudai, C; Sabatelli, P; Toti, P; Malandrini, A; Luzi, P; Maraldi, NM; Valensin, PE; Merlini, L;
Indirizzi:
Ist Ortoped Rizzoli, Lab Neuromuscular Pathol, I-40136 Bologna, Italy Ist Ortoped Rizzoli Bologna Italy I-40136 Pathol, I-40136 Bologna, Italy Univ Siena, Inst Neurol Sci, Neuropathol Lab, I-53100 Siena, Italy Univ Siena Siena Italy I-53100 ci, Neuropathol Lab, I-53100 Siena, Italy Univ Siena, Microbiol Sect, Dept Mol Biol, I-53100 Siena, Italy Univ Siena Siena Italy I-53100 Sect, Dept Mol Biol, I-53100 Siena, Italy Ist Ortoped Rizzoli, Lab Cell Biol & Electron Microscopy, I-40136 Bologna,Italy Ist Ortoped Rizzoli Bologna Italy I-40136 roscopy, I-40136 Bologna,Italy Univ Siena, Inst Pathol, I-53100 Siena, Italy Univ Siena Siena Italy I-53100 Siena, Inst Pathol, I-53100 Siena, Italy CNR Bologna, Inst Normal & Pathol Cytomorphol, Bologna, Italy CNR BolognaBologna Italy t Normal & Pathol Cytomorphol, Bologna, Italy
Titolo Testata:
ACTA NEUROPATHOLOGICA
fascicolo: 3, volume: 99, anno: 2000,
pagine: 271 - 276
SICI:
0001-6322(200003)99:3<271:HCVIAM>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBROSPINAL-FLUID; COLD ACTIVATION; DNA; CRYOGLOBULINEMIA; COMPLEMENT; SERA;
Keywords:
hepatitis C; polymerase chain reaction; inflammatory myopathy; complement membrane attack complex; muscle biopsy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Villanova, M Ist Ortoped Rizzoli, Lab Neuromuscular Pathol, Viale Pupilli 1, I-40136 Bologna, Italy Ist Ortoped Rizzoli Viale Pupilli 1 Bologna Italy I-40136 ly
Citazione:
M. Villanova et al., "Hepatitis C virus infection and myositis: a polymerase chain reaction study", ACT NEUROP, 99(3), 2000, pp. 271-276

Abstract

Muscle biopsy tissue from a patient with chronic hepatitis, who was hepatitis C virus (HCV) positive and showed slight weakness of the right arm and leg en associated with increased serum creatine kinase levels, was studied using immunocytochemical and polymerase chain reaction (PCR) techniques. Muscle biopsy showed changes compatible with an inflammatory myopathy. Immunohistochemical studies included the use of monoclonal antibodies against human T lymphocytes, macrophages, immunoglobulins, major histocompatibility complex class I molecules (MHC-I), and the neoantigens of the terminal C5b-9 complement membrane attack complex (MAC). In addition to confirming the potential importance of cytotoxic T cells and MHC-I antigen expression in inducing muscle pathology, we demonstrated MAC deposition and the presence of HCV-RNA in the muscle of our patient, suggesting that direct involvement of the virus leading to complement activation might be important in inducing muscle damage.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 23:55:52