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Titolo:
Genetic background of osteoporosis
Autore:
Obermayer-Pietsch, B; Chararas, C; Kotschan, S; Walter, D; Leb, G;
Indirizzi:
Graz Univ, Dept Internal Med, Div Endocrinol & Nucl Med, A-8036 Graz, Austria Graz Univ Graz Austria A-8036 ndocrinol & Nucl Med, A-8036 Graz, Austria
Titolo Testata:
ACTA MEDICA AUSTRIACA
fascicolo: 1, volume: 27, anno: 2000,
pagine: 18 - 22
SICI:
0303-8173(2000)27:1<18:GBOO>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
VITAMIN-D-RECEPTOR; BONE-MINERAL DENSITY; POSTMENOPAUSAL JAPANESE WOMEN; SP1 BINDING-SITE; I ALPHA-1 GENE; PREMENOPAUSAL WOMEN; CALCIUM INTAKE; LUMBAR-SPINE; WHITE WOMEN; POLYMORPHISM;
Keywords:
osteoporosis; genetic basis; candidate genes; polymorphisms; environmental influences;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
70
Recensione:
Indirizzi per estratti:
Indirizzo: Obermayer-Pietsch, B Graz Univ, Dept Internal Med, Div Endocrinol & Nucl Med, Aeunbruggerpl 15,A-8036 Graz, Austria Graz Univ Aeunbruggerpl 15 Graz Austria A-8036 stria
Citazione:
B. Obermayer-Pietsch et al., "Genetic background of osteoporosis", ACT MED AUS, 27(1), 2000, pp. 18-22

Abstract

Osteoporosis is a systemic disorder of decreased skeletal mass as measuredby bone mineral density (BMD), and disturbed skeletal architecture and function which results in an increased risk for bone fractures with consecutively increased morbidity and mortality. Twin and family studies have shown an important genetic component of BMD of about 40-60 %. This exceeds other well known factors influencing BMD such as environmental factors like dietary calcium, physical activity or several drugs and diseases. Therefore, interest increased in the genetic background of bone mineral density. Polymorphisms of the Vitamin D receptor gene were the first to be published in this area. Studies on other loci or candidate genes such as the estrogen receptor gene or the collagen type I alpha 1 gene also showed associations with bone mineral density that could explain at least a part of the genetic background of osteoporosis. Recently published data suggest that these genetic markers of bone metabolism are important in interaction with each other or incertain bone-affecting diseases. In the future, genetic studies on osteoporosis will have to screen further relevant genes and markers for bone metabolism as well as to evaluate the complex interactions of genetic influences, so that it would be possible to calculate a patient's individual risk forosteoporosis in the context of environmental influences.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 10:02:16