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Titolo:
Coevolution of host and virus: The pathogenesis of virulent and attenuatedstrains of myxoma virus in resistant and susceptible European rabbits
Autore:
Best, SM; Kerr, PJ;
Indirizzi:
CSIRO, Wildlife & Ecol, Pest Anim Control Cooperat Res Ctr, Canberra, ACT 2601, Australia CSIRO Canberra ACT Australia 2601 Res Ctr, Canberra, ACT 2601, Australia Australian Natl Univ, Div Biochem & Mol Biol, Canberra, ACT 0200, Australia Australian Natl Univ Canberra ACT Australia 0200 rra, ACT 0200, Australia
Titolo Testata:
VIROLOGY
fascicolo: 1, volume: 267, anno: 2000,
pagine: 36 - 48
SICI:
0042-6822(20000201)267:1<36:COHAVT>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
T-LYMPHOCYTES; ECTROMELIA VIRUS; RECEPTOR HOMOLOG; VIRAL VIRULENCE; INFECTION; INTERFERON; PROTEIN; CELLS; CHEMOKINES; IMMUNITY;
Keywords:
myxoma virus; pathogenesis; rabbits; resistance; coevolution;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Kerr, PJ CSIRO, Wildlife & Ecol, Pest Anim Control Cooperat Res Ctr, GPO Box 284, Canberra, ACT 2601, Australia CSIRO GPO Box 284 Canberra ACT Australia 2601 ACT 2601, Australia
Citazione:
S.M. Best e P.J. Kerr, "Coevolution of host and virus: The pathogenesis of virulent and attenuatedstrains of myxoma virus in resistant and susceptible European rabbits", VIROLOGY, 267(1), 2000, pp. 36-48

Abstract

Myxoma virus was introduced into the European rabbit population of Australia In 1950. Although the Virus was initially highly lethal in rabbits, there was rapid selection for less virulent strains of virus and innately resistant rabbits. To investigate the basis of resistance to myxoma virus, we have compared the pathogensis of the virulent strain of myxoma virus originally released into Australia and an attenuated, naturally derived field strain of myxoma virus. This was done in laboratory rabbits, which have not beenselected for resistance, and in wild rabbits that have developed significant resistance. Wild rabbits were able to recover from infection with virus that was always lethal in laboratory rabbits. Laboratory rabbits were able to control and recover from infection with attenuated virus. This virus caused a trivial disease in wild rabbits. There was little difference between laboratory and wild rabbits in titers of either virulent or attenuated virus in the skin at the inoculation site. However, resistant wild rabbits had a 10- to 100-fold lower titer of virulent virus within the lymph node draining the inoculation sire and controlled virus replication in tissues distalto the draining lymph node. Replication of virus in lymphocytes or fibroblasts cultured from wild and laboratory rabbits demonstrated that resistancewas not due to altered cellular permissivity for replication. Neutralizingantibodies were present in both susceptible and resistant rabbits, suggesting that these have no significant role in resistance. We hypothesise that resistance is due to an enhanced innate immune response that allows the rabbit to mount an effective cellular immune response. (C) 2000 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 10:21:55