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Titolo:
Carcinoembryonic antigen and carbohydrate antigen 19-9-producing adenocarcinoma of the prostate: Report of an autopsy case
Autore:
Kodama, S; Itoh, H; Ide, H; Kataoka, H; Takahara, T; Nagano, M; Hamasuna, R; Koono, M; Osada, Y;
Indirizzi:
Miyazaki Med Coll, Dept Urol, Kiyotake, Miyazaki 8891692, Japan Miyazaki Med Coll Kiyotake Miyazaki Japan 8891692 Miyazaki 8891692, Japan
Titolo Testata:
UROLOGIA INTERNATIONALIS
fascicolo: 3, volume: 63, anno: 1999,
pagine: 193 - 197
SICI:
0042-1138(1999)63:3<193:CAACA1>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
CARCINOMA; MARKERS; CANCER;
Keywords:
prostate; adenocarcinoma, metastatic; carcinoembryonic antigen; carbohydrate antigen 19-9; prostate-specific antigen; prostatic acid phosphatase; autopsy; immunohistochemistry;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
14
Recensione:
Indirizzi per estratti:
Indirizzo: Osada, Y Miyazaki Med Coll, Dept Urol, 5200 Kihara, Kiyotake, Miyazaki 8891692, Japan Miyazaki Med Coll 5200 Kihara Kiyotake Miyazaki Japan 8891692 pan
Citazione:
S. Kodama et al., "Carcinoembryonic antigen and carbohydrate antigen 19-9-producing adenocarcinoma of the prostate: Report of an autopsy case", UROL INTERN, 63(3), 1999, pp. 193-197

Abstract

Prostate-specific antigen (PSA) and prostatic acid phosphatase (PAP) are well known as specific tumor markers of prostate cancer, but carcinoembryonic antigen (CEA)and carbohydrate antigen 19-9 (CA19-9)-producing adenocarcinoma originating in the prostate is rare. We report here a case of prostaticadenocarcinoma positive for these 4 tumor markers in a 50-year-old man whohad initially complained about chest pain due to metastatic bone tumor. Inspite of the extensive treatment involving hormone and radiation therapy, the patient died of rapid tumor extension only 4 months after initial diagnosis, Autopsy revealed multiple metastases to the bone, liver, lungs and lymph nodes. Histologically, two types of adenocarcinoma were involved in both primary prostate and metastatic sites: one was a poorly differentiated adenocarcinoma positive for PSA and PAP but not CEA or CA19-9, and the other one was a less differentiated adenocarcinoma partially positive for CEA andCA19-9 but not for PSA or PAP. Based on this case and previous cases by review of the literature, CEA- and CA19-9-producing adenocarcinoma of the prostate was suggested to rapidly progress with multiple metastases and to show poor prognosis with strong resistance to any treatment, Copyright (C) 2000 S. Karger AG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 15:56:21