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Titolo:
Antiplatelet drugs attenuate progression of carotid intima-media thicknessin subjects with type 2 diabetes
Autore:
Kodama, M; Yamasaki, Y; Sakamoto, K; Yoshioka, R; Matsuhisa, M; Kajimoto, Y; Kosugi, K; Ueda, N; Hori, M;
Indirizzi:
Osaka Univ, Grad Sch Med, Dept Internal Med & Therapeut, Suita, Osaka 5650871, Japan Osaka Univ Suita Osaka Japan 5650871 erapeut, Suita, Osaka 5650871, Japan Osaka Police Hosp, Tennoji Ku, Osaka 5430035, Japan Osaka Police Hosp Osaka Japan 5430035 , Tennoji Ku, Osaka 5430035, Japan
Titolo Testata:
THROMBOSIS RESEARCH
fascicolo: 4, volume: 97, anno: 2000,
pagine: 239 - 245
SICI:
0049-3848(20000215)97:4<239:ADAPOC>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
ARTERIAL-WALL THICKNESS; ATHEROSCLEROSIS; TICLOPIDINE; CHOLESTEROL; PREVALENCE;
Keywords:
intima-media thickness; type 2 diabetes; antiplatelet drug; asymptomatic;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Yamasaki, Y Osaka Univ, Grad Sch Med, Dept Internal Med & Therapeut, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan Osaka Univ 2-2 Yamadaoka Suita Osaka Japan 5650871 0871, Japan
Citazione:
M. Kodama et al., "Antiplatelet drugs attenuate progression of carotid intima-media thicknessin subjects with type 2 diabetes", THROMB RES, 97(4), 2000, pp. 239-245

Abstract

The intima-media thickness of the carotid artery has been established as asurrogate of definite atherosclerosis in subjects with high risk of vascular events. This study was done to evaluate the effectiveness of long-term antiplatelet therapy in attenuating progression of the intima-media thickness of the carotid artery of subjects with type 2 diabetes. Subjects who had an intima-media thickness over the threshold of the normal subjects but showed no symptoms of vascular events were randomly divided into groups given antiplatelet drugs [ticlopidine (n = 34) or a small dose of aspirin (n = 40)] or no drugs (n = 74). For the follow-up period (3.0 +/- 0.06 years), thesubjects not given antiplatelet drugs showed a significantly higher progression of intima-media thickness (0.067 +/- 0.009 mm/year) than those given ticlopidine (0.034 +/- 0.013 mm/year) or aspirin (0.033 +/- 0.010 mm/year). Stepwise multi variant regression analysis showed that long-term administration of ticlopidine or aspirin significantly reduced the progression of intima-media thickness of diabetic subjects by 0.041 mm/year or 0.032 mm/year, respectively. These data indicated that despite differences of their pharmacological mechanisms, antiplatelet drugs could attenuate the progression of intima-media thickness of the carotid artery wall of asymptomatic type 2diabetics who had early-stage carotid atherosclerosis. (C) 2000 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 04:24:37