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Titolo:
Oral administration of the dopamine prodrug docarpamine shortens need for drip infusion of dopamine in patients with low cardiac output syndrome after cardiac surgery
Autore:
Matsubayashi, K; Ueda, Y; Ogino, H; Sugita, T; Sakakibara, Y; Matsuyama, K; Nomoto, T;
Indirizzi:
Tenri Hosp, Dept Cardiovasc Surg, Nara 6328552, Japan Tenri Hosp Nara Japan 6328552 Dept Cardiovasc Surg, Nara 6328552, Japan
Titolo Testata:
THORACIC AND CARDIOVASCULAR SURGEON
fascicolo: 6, volume: 47, anno: 1999,
pagine: 352 - 356
SICI:
0171-6425(199912)47:6<352:OAOTDP>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
TA-870; DOGS;
Keywords:
docarpamine; dopamine prodrug; low cardiac output syndrome; post cardiac surgery;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Matsubayashi, K Tenri Hosp, Dept Cardiovasc Surg, 200 Mishima Cho, Nara 6328552, Japan Tenri Hosp 200 Mishima Cho Nara Japan 6328552 8552, Japan
Citazione:
K. Matsubayashi et al., "Oral administration of the dopamine prodrug docarpamine shortens need for drip infusion of dopamine in patients with low cardiac output syndrome after cardiac surgery", THOR CARD S, 47(6), 1999, pp. 352-356

Abstract

Background: Docarpamine (DOC) is a dopamine prodrug which can be orally administered. It has been found that oral docarpamine transforms into dopamine in vivo, and increases cardiac output and renal blood flow as effectivelyas intravenous dopamine. Methods: We reviewed the records of 26 patients who had developed low cardiac output syndrome (LOS) after cardiac surgery and received docarpamine during the early postoperative course. Five patientsdiscontinued docarpamine within 2 days due to arrhythmia. There were 3 hospital deaths. The remaining 18 patients were divided into two groups according to the timing of docarpamine administration. In group A docarpamine wasadministered during and after weaning from intravenous catecholamines, in group B only on demand after weaning from intravenous catecholamines. Results: There were 12 patients in group A and 6 in group B, and the severity ofLOS was relatively milder in group B than in group A. Stable hemodynamics and sufficient daily urinary output were maintained by oral administration of DOC in both groups just as well as by drip infusion of catecholamines. Conclusion: Sinse continuous drip infusion of catecholamine commonly slows recovery in LOS patients, it is considered that switching from drip infusionof catecholamines to oral DOC administration is safe and useful for earlier recovery in LOS patients after cardiac surgery.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/04/20 alle ore 01:44:10