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Titolo:
Synthesis of 3 '-S-(2-aminoethylthio)-3 '-deoxythymidine-5 '-triphosphates
Autore:
Wojczewski, C; Engels, JW;
Indirizzi:
Univ Frankfurt, Inst Organ Chem, D-60439 Frankfurt, Germany Univ Frankfurt Frankfurt Germany D-60439 hem, D-60439 Frankfurt, Germany
Titolo Testata:
SYNTHESIS-STUTTGART
fascicolo: 1, , anno: 2000,
pagine: 149 - 153
SICI:
0039-7881(200001):1<149:SO3'''>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
FLUORESCENT NUCLEOTIDE; LABELED OLIGONUCLEOTIDES; ENERGY-TRANSFER; DNA-SYNTHESIS; 5'-TRIPHOSPHATES; DERIVATIVES; 2'-DEOXYISOINOSINE; TERMINATORS; NUCLEOSIDES; STABILITY;
Keywords:
fluorescent nucleotides; thioether; triphosphates; chromophores; ring opening;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Physical, Chemical & Earth Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Engels, JW Univ Frankfurt, Inst Organ Chem, Marie Curie Str 11, D-60439 Frankfurt, Germany Univ Frankfurt Marie Curie Str 11 Frankfurt Germany D-60439 ny
Citazione:
C. Wojczewski e J.W. Engels, "Synthesis of 3 '-S-(2-aminoethylthio)-3 '-deoxythymidine-5 '-triphosphates", SYNTHESIS-S, (1), 2000, pp. 149-153

Abstract

3'-S-(2-N-(t-Butyloxycarbonyl)aminoethylthio)-3'-deoxy-5'-O-(4,4'-dimethoxytrityl)thymidine (3) was synthesized by treating 5'-O-(4,4'-dimethoxytrityl)-2,3'-anhydrothymidine (2) with t-butyl N-(2-mercaptoethyl)carbamate (1) and DBU. Compound 3 was further converted to 3'-S-(2-N-(t-butyloxycarbonyl)aminoethylthio)-3'-deoxythymidine-5'-triphosphate (5) and 3'-S-(2-aminoethylthio)-3'-deoxythymidine-5'-triphosphate (9). The latter compound was labeled with a near-IR fluorescent dye.

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Documento generato il 19/09/20 alle ore 09:00:14