Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Profile of cytokine production during the inhibition of acute xenograft rejection
Autore:
Kishimoto, K; Furukawa, K; Ashizuka, S; Sawada, T; Ayabe, H;
Indirizzi:
Nagasaki Univ, Sch Med, Dept Surg 1, Nagasaki 8528501, Japan Nagasaki Univ Nagasaki Japan 8528501 ept Surg 1, Nagasaki 8528501, Japan
Titolo Testata:
SURGERY TODAY-THE JAPANESE JOURNAL OF SURGERY
fascicolo: 2, volume: 30, anno: 2000,
pagine: 159 - 162
SICI:
0941-1291(2000)30:2<159:POCPDT>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
CD4+ T-CELLS; TRANSPLANTATION TOLERANCE; PERIPHERAL TOLERANCE; MONOCLONAL-ANTIBODY; ALLOGRAFT-REJECTION; CLONAL ANERGY; INDUCTION; SURVIVAL; MICE; SUBSETS;
Keywords:
xenotransplantation; acute rejection; immunotherapy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Kishimoto, K Nagasaki Univ, Sch Med, Dept Surg 1, 1-7-1 Sakamoto, Nagasaki8528501, Japan Nagasaki Univ 1-7-1 Sakamoto Nagasaki Japan 8528501 1, Japan
Citazione:
K. Kishimoto et al., "Profile of cytokine production during the inhibition of acute xenograft rejection", SURG TODAY, 30(2), 2000, pp. 159-162

Abstract

Th2 cells have been shown to exert cell-mediated immune responses in vitro; therefore, the present study was conducted to investigate the cellular mechanisms of the longterm survival of cardiac xenografts by measuring cytokine production from recipient lymphocytes. Xenogeneic heart grafts from Lewis rats were transplanted into C57BL/6 mice, and the recipients were intravenously injected with H57-597 at the time of transplantation. The productionof Th1 cytokines, namely, interleukin (IL)-2 and interferon (IFN)-gamma, and Th2 cytokines, namely, IL-4 and IL-10, from mixed lymphocyte culture cells was assayed by enzyme-linked immunosorbent assay. Splenocytes from the xenograft recipients treated with H57-597 produced significantly lower levels of IL-2, IFN-gamma, IL-4, and IL-10 than those from the untreated recipients, 100 days after transplantation. The findings of this study indicate that the long-term survival of cardiac xenografts induced by H57-597 is mediated by the inhibition of Th0, or both the Th1 and Th2 response.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/01/21 alle ore 22:54:00