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Titolo:
Hepatotoxixity associated to the use of amoxicillin-clavulanic acid
Autore:
Soza, A; Riquelme, F; Alvarez, M; Duarte, I; Glasinovic, JC; Arrese, M;
Indirizzi:
Pontificia Univ Catolica Chile, Fac Med, Dept Gastroenterol, Santiago, Chile Pontificia Univ Catolica Chile Santiago Chile oenterol, Santiago, Chile Pontificia Univ Catolica Chile, Fac Med, Dept Anat Patol, Santiago, Chile Pontificia Univ Catolica Chile Santiago Chile at Patol, Santiago, Chile
Titolo Testata:
REVISTA MEDICA DE CHILE
fascicolo: 12, volume: 127, anno: 1999,
pagine: 1487 - 1491
SICI:
0034-9887(199912)127:12<1487:HATTUO>2.0.ZU;2-K
Fonte:
ISI
Lingua:
SPA
Soggetto:
URSODEOXYCHOLIC ACID; INTRAHEPATIC CHOLESTASIS; HEPATITIS; COMBINATION; AUGMENTIN; UTILITY;
Keywords:
amoxicillin; cholestasis, intrahepatic; clavulanic acids; hepatitis, toxic; urosodeoxycholic acid;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Arrese, M Pontificia Univ Catolica Chile, Fac Med, Dept Gastroenterol, Marcoleta 367, Santiago, Chile Pontificia Univ Catolica Chile Marcoleta 367 Santiago Chile le
Citazione:
A. Soza et al., "Hepatotoxixity associated to the use of amoxicillin-clavulanic acid", REV MED CHI, 127(12), 1999, pp. 1487-1491

Abstract

We report of 72 years old diabetic male that, after the use of combined amoxicillin-clavulanic acid, developed pruritus and jaundice. Liver function tests showed serum total bilirubin of 4.3 mg/dL aspartate aminotransferase 140 U/l (normal <35 U/L), alanine aminotransferase 470 U/L (normal <40) andalkaline phosphatases of 400 U/L (normal <100). Serology for hepatitis A, B and C viruses was negative, ERCP showed a normal biliary tree and liver biopsy disclosed a cholestatic hepatitis. Ursodeoxycholic was started to relieve pruritus. Liver function tests improved shortly thereafter, suggestingthat this drug may be useful in the treatment of drug induced cholestasis.

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Documento generato il 20/02/20 alle ore 12:51:30