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Titolo:
Global relationship between anatomical connectivity and activity propagation in the cerebral cortex
Autore:
Kotter, R; Sommer, FT;
Indirizzi:
Univ Dusseldorf, C&O Vogt Brain Res Inst, D-40225 Dusseldorf, Germany UnivDusseldorf Dusseldorf Germany D-40225 , D-40225 Dusseldorf, Germany Univ Ulm, Dept Neural Informat Proc, D-89069 Ulm, Germany Univ Ulm Ulm Germany D-89069 Neural Informat Proc, D-89069 Ulm, Germany
Titolo Testata:
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES
fascicolo: 1393, volume: 355, anno: 2000,
pagine: 127 - 134
SICI:
0962-8436(20000129)355:1393<127:GRBACA>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEURAL SYSTEMS; LIMBIC SYSTEM; VISUAL AREAS; CAT; ANTICONVULSANT; ORGANIZATION; GLYCINE;
Keywords:
cat cerebral cortex; association fibres; functional connectivity; strychnine neuronography; structure-function relationship; computer model;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Kotter, R Univ Dusseldorf, C&O Vogt Brain Res Inst, D-40225 Dusseldorf, Germany Univ Dusseldorf Dusseldorf Germany D-40225 Dusseldorf, Germany
Citazione:
R. Kotter e F.T. Sommer, "Global relationship between anatomical connectivity and activity propagation in the cerebral cortex", PHI T ROY B, 355(1393), 2000, pp. 127-134

Abstract

Anatomical connectivity is a prerequisite for cooperative interactions between cortical areas, but it has yet to be demonstrated that association fibre networks determine the macroscopical flow of activity in the cerebral cortex. To test this notion, we constructed a large-scale model of cortical areas whose interconnections were based on published anatomical data from tracing studies. Using this model we simulated the propagation of activity inresponse to activation of individual cortical areas and compared the resulting topographic activation patterns to electrophysiological observations on the global spread of epileptic activity following intracortical stimulation. Here we show that a neural network with connectivity derived from experimental data reproduces cortical propagation of activity significantly better than networks with different types of neighbourhood-based connectivity or random connections. Our results indicate that association fibres and their relative connection strengths are useful predictors of global topographicactivation patterns in the cerebral cortex. This global structure-functionrelationship may open a door to explicit interpretation of cortical activation data in terms of underlying anatomical connectivity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 05:01:25