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Titolo:
Atrophy and high intensity lesions: Complementary neurobiological mechanisms in late-life major depression
Autore:
Kumar, A; Bilker, W; Jin, ZS; Udupa, J;
Indirizzi:
Univ Calif Los Angeles, Inst Neuropsychiat, Los Angeles, CA 90024 USA UnivCalif Los Angeles Los Angeles CA USA 90024 Los Angeles, CA 90024 USA Univ Penn, Dept Radiol, Philadelphia, PA 19104 USA Univ Penn PhiladelphiaPA USA 19104 pt Radiol, Philadelphia, PA 19104 USA
Titolo Testata:
NEUROPSYCHOPHARMACOLOGY
fascicolo: 3, volume: 22, anno: 2000,
pagine: 264 - 274
SICI:
0893-133X(200003)22:3<264:AAHILC>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBRAL BLOOD-FLOW; DEFINED VASCULAR DEPRESSION; MEDICAL COMORBIDITY; ALZHEIMERS-DISEASE; MINOR DEPRESSION; PHYSICAL HEALTH; MOOD DISORDERS; MRI; ENCEPHALOPATHY; BRAIN;
Keywords:
late-life depression; atrophy; major depression; magnetic resonance imaging; geriatric depression; high intensity lesions; medical comorbidity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
74
Recensione:
Indirizzi per estratti:
Indirizzo: Kumar, A Univ Calif Los Angeles, Inst Neuropsychiat, 37-384B,760 Westwood Plaza, Los Angeles, CA 90024 USA Univ Calif Los Angeles 37-384B,760 Westwood Plaza Los Angeles CA USA 90024
Citazione:
A. Kumar et al., "Atrophy and high intensity lesions: Complementary neurobiological mechanisms in late-life major depression", NEUROPSYCH, 22(3), 2000, pp. 264-274

Abstract

The primary objective of our study was to examine the role of atrophy, high intensity lesions and medical comorbidity in the pathophysiology of majordepressive disorder in the elderly (late-life MDD). Our sample was comprised of 51 patients with late-life MDD and 30 non-depressed controls. All subjects were scanned on 1.5 tesla magnetic resonance imaging scanner (MRI) and absolute and normalized measures of brain and lesion volumes were obtained and used for comparison between groups. Patients with MDD had significantly smaller frontal lobe volumes, together with larger whole brain lesion volumes when compared with controls (p <.05). Whole brain lesion volumes correlated significantly (r = 0.41, p = .006) with overall medical comorbidity. The odds ratio (OR) for existing MDD increases significantly with a decrease in frontal lobe volume and an increase in whole brain lesion volumes (p < .05). Our findings suggest that atrophy and high intensity lesions represent relatively independent pathways to late-life MDD. While medical disorders lead to neuropathological changes that are captured on MR imaging as high intensity signals, atrophy may represent a relatively autonomous phenomenon. These findings have broad implications for the pathophysiology of mood disorders and suggest that complementary neurobiological processes may leadto cumulative neuronal injury thereby predisposing to clinical depression.[Neuropsychopharmacology 22:264-274, 2000] (C) 2000 American College of Neuropsychopharmacology. Published by Elsevier Science Inc.

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Documento generato il 09/04/20 alle ore 11:02:53