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Titolo:
The effects of early rearing environment on the development of GABA(A) andcentral benzodiazepine receptor levels and novelty-induced fearfulness in the rat
Autore:
Caldji, C; Francis, D; Sharma, S; Plotsky, PM; Meaney, MJ;
Indirizzi:
McGill Univ, Douglas Hosp, Res Ctr, Dev Neuroendocrinol Lab,Dept Psychiat,Montreal, PQ H4H 1R3, Canada McGill Univ Montreal PQ Canada H4H 1R3 chiat,Montreal, PQ H4H 1R3, Canada McGill Univ, Douglas Hosp, Res Ctr, Dev Neuroendocrinol Lab,Dept Neurol, Montreal, PQ H4H 1R3, Canada McGill Univ Montreal PQ Canada H4H 1R3 urol, Montreal, PQ H4H 1R3, Canada McGill Univ, Douglas Hosp, Res Ctr, Dev Neuroendocrinol Lab,Dept Neurosurg, Montreal, PQ H4H 1R3, Canada McGill Univ Montreal PQ Canada H4H 1R3 surg, Montreal, PQ H4H 1R3, Canada Emory Univ, Dept Psychiat & Behav Sci, Atlanta, GA 30322 USA Emory Univ Atlanta GA USA 30322 ychiat & Behav Sci, Atlanta, GA 30322 USA
Titolo Testata:
NEUROPSYCHOPHARMACOLOGY
fascicolo: 3, volume: 22, anno: 2000,
pagine: 219 - 229
SICI:
0893-133X(200003)22:3<219:TEOERE>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTICOTROPIN-RELEASING FACTOR; HYPOTHALAMIC PARAVENTRICULAR NUCLEUS; CENTRAL AMYGDALOID NUCLEUS; ACOUSTIC STARTLE; PANIC DISORDER; MATERNAL-CARE; STRESS; BINDING; BRAIN; SYSTEM;
Keywords:
fear; novelty; GABA(A) receptor; central benzodiazepine receptor; maternal separation; early experience;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
61
Recensione:
Indirizzi per estratti:
Indirizzo: Meaney, MJ McGill Univ, Douglas Hosp, Res Ctr, Dev Neuroendocrinol Lab,Dept Psychiat,6875 LaSalle Blvd, Montreal, PQ H4H 1R3, Canada McGill Univ 6875LaSalle Blvd Montreal PQ Canada H4H 1R3 Canada
Citazione:
C. Caldji et al., "The effects of early rearing environment on the development of GABA(A) andcentral benzodiazepine receptor levels and novelty-induced fearfulness in the rat", NEUROPSYCH, 22(3), 2000, pp. 219-229

Abstract

We compared the effects of handling or maternal separation from the day following birth until postnatal day 14 on behavioral responses to novelty andon GABA(A) and central benzodiazepine (CBZ) receptor levels in the rat. Asadults, handled animals showed reduced startle responsivity, increased exploration in a novel open field, and decreased novelty-induced suppression of feeding relative to the handled (H) and/or maternal separation (MS) groups. As compared with handled animals, both nonhandled (NH) and MS animals displayed: (1) reduced GABA(A) receptor levels in the locus coeruleus (LC) and the n. tractus solitarius (NTS); (2) reduced CBZ receptor sites in the central and lateral n. of the amygdala, the frontal cortex, and in the LC andNTS; and (3) reduced levels of the mRNA for the gamma 2 subunit of the GABA(A) receptor complex, which confers high affinity BZ binding, in the amygdaloid nucleic as well as the he LC and NTS. Both the amygdala and the ascending nonadrenergic systems have been considered as critical sites for the anxiolytic effects of benzodiazepines. These data suggest that early life events influence the development of the GABA(A) receptor system, thus altering the expression of fearfulness in adulthood. [Neuropsychopharmacology 22:229-229, 2000] (C) 2000 American College of Neuropsychopharmacology. Published by Elsevier Science Inc.

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Documento generato il 26/01/20 alle ore 01:19:19