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Titolo:
Acute and chronic activation of the mu-opioid receptor with the endogenousligand endomorphin differentially regulates adenylyl cyclase isozymes
Autore:
Nevo, I; Avidor-Reiss, T; Levy, R; Bayewitch, M; Vogel, Z;
Indirizzi:
Weizmann Inst Sci, Dept Neurobiol, IL-76100 Rehovot, Israel Weizmann Inst Sci Rehovot Israel IL-76100 biol, IL-76100 Rehovot, Israel
Titolo Testata:
NEUROPHARMACOLOGY
fascicolo: 3, volume: 39, anno: 2000,
pagine: 364 - 371
SICI:
0028-3908(2000)39:3<364:AACAOT>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
BETA-GAMMA-SUBUNITS; INHIBITORY RECEPTORS; OPIATE-RECEPTOR; SPINAL-CORD; RAT-BRAIN; CELLS; MODULATION; PROTEIN; SUPERSENSITIVITY; SUPERACTIVATION;
Keywords:
endomorphins; opioid receptor; adenylyl cyclase; isozymes; inhibition; superactivation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Vogel, Z Weizmann Inst Sci, Dept Neurobiol, IL-76100 Rehovot, Israel Weizmann Inst Sci Rehovot Israel IL-76100 76100 Rehovot, Israel
Citazione:
I. Nevo et al., "Acute and chronic activation of the mu-opioid receptor with the endogenousligand endomorphin differentially regulates adenylyl cyclase isozymes", NEUROPHARM, 39(3), 2000, pp. 364-371

Abstract

While acute activation of G(i/o)-coupled receptors leads to inhibition of adenylyl cyclase, chronic activation of such receptors produces an increasein cyclic AMP accumulation, particularly evident upon withdrawal of the inhibitory agonist. This phenomenon has been referred to as adenylyl cyclase superactivation and is believed to play an important role in opiate addiction. Nine adenylyl cyclase isozymes have been recently identified and shown by us to be differentially regulated by acute and chronic inhibitory receptor activation Using COS-7 cells cotransfected with various adenylyl cyclaseisozymes, we examined here whether the endomorphins (the most recently discovered of the four classes of endogenous opioid peptides, and which interact selectively with the I-I receptor) are able to induce inhibition/superactivation of representatives from the various adenylyl cyclase isozyme classes. Here, we show that adenylyl cyclase types I and V were inhibited by acute endomorphin application and superactivated upon chronic exposure, while adenylyl cyclase type II was stimulated by acute and "superinhibited'' by chronic endomorphin exposure. These results show that the endomorphins are capable of regulating adenylyl cyclase activity and that different adenylyl cyclase isozymes respond differently to these endogenous ligands. (C) 2000 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/07/20 alle ore 00:48:50