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Titolo:
The living shunt: A tissue engineering approach in the treatment of hydrocephalus
Autore:
Lee, IW; Vacanti, JP; Taylor, GA; Madsen, JR;
Indirizzi:
Childrens Hosp, Dept Neurosurg, Boston, MA 02115 USA Childrens Hosp Boston MA USA 02115 , Dept Neurosurg, Boston, MA 02115 USA Childrens Hosp, Dept Surg, Boston, MA 02115 USA Childrens Hosp Boston MA USA 02115 Hosp, Dept Surg, Boston, MA 02115 USA Childrens Hosp, Dept Radiol, Boston, MA 02115 USA Childrens Hosp Boston MA USA 02115 osp, Dept Radiol, Boston, MA 02115 USA Harvard Univ, Sch Med, Dept Surg, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 Sch Med, Dept Surg, Boston, MA 02115 USA Harvard Univ, Sch Med, Dept Radiol, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 h Med, Dept Radiol, Boston, MA 02115 USA
Titolo Testata:
NEUROLOGICAL RESEARCH
fascicolo: 1, volume: 22, anno: 2000,
pagine: 105 - 110
SICI:
0161-6412(200001)22:1<105:TLSATE>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
VENTRICULOPERITONEAL SHUNTS; CELL TRANSPLANTATION; CARTILAGE; POLYMER; RATS; BONE;
Keywords:
tissue engineering; hydrocephalus; ventriculoperitoneal shunt; chondrocytes; tissue culture; animal model;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Madsen, JR Childrens Hosp, Dept Neurosurg, 300 Longwood Ave, Boston, MA 02115 USA Childrens Hosp 300 Longwood Ave Boston MA USA 02115 A 02115 USA
Citazione:
I.W. Lee et al., "The living shunt: A tissue engineering approach in the treatment of hydrocephalus", NEUROL RES, 22(1), 2000, pp. 105-110

Abstract

Tissue engineering is the use of cultured cells seeded into biodegradable polymers to create custom designed, living implantable devices. As a first approach to the use of this technique in the treatment of hydrocephalus, wehave prepared chondrocyte-seeded polyglycolic acid (PGA) tubes coated withpolylactic glycolic acid (PGLA), implanted initially with thin silastic stents removed four weeks after shunt insertion. The use of bovine xenograft cells in athymic (nude) rats resulted in more efficient seeding with chondrocytes, stiffer tube walls, and better patency. When implanted in 6-week-old rats made hydrocephalic by cisternal injection of kaolin at 4 weeks of age, six of eight 'living shunts' remained patent to radio-opaque contrast injection at two weeks after stent removal. At four weeks after stent removal, all four of the shunts had occluded at the ventricular end, three of the four apparently due to growth of the animal. We conclude that polymer type,cell type, and cell density will require considerable optimization, but a working tissue engineered shunt is feasible and may one day address some problems of interactions of living tissue and inert polymer.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 14:50:16