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Titolo:
L-type calcium channels in the hippocampus and cerebellum of Alzheimer's disease brain tissue
Autore:
Coon, AL; Wallace, DR; Mactutus, CF; Booze, RM;
Indirizzi:
Univ Kentucky, Dept Anat & Neurobiol, Lexington, KY 40536 USA Univ Kentucky Lexington KY USA 40536 & Neurobiol, Lexington, KY 40536 USA Univ Kentucky, Med Ctr, Sanders Brown Ctr Aging, Lexington, KY 40536 USA Univ Kentucky Lexington KY USA 40536 n Ctr Aging, Lexington, KY 40536 USA Oklahoma State Univ, Coll Osteopath Med, Dept Pharmacol & Physiol, Tulsa, OK USA Oklahoma State Univ Tulsa OK USA Dept Pharmacol & Physiol, Tulsa, OK USA Univ Kentucky, THRI, Coll Pharm, Div Pharmaceut Sci, Lexington, KY 40536 USA Univ Kentucky Lexington KY USA 40536 rmaceut Sci, Lexington, KY 40536 USA
Titolo Testata:
NEUROBIOLOGY OF AGING
fascicolo: 6, volume: 20, anno: 1999,
pagine: 597 - 603
SICI:
0197-4580(199911/12)20:6<597:LCCITH>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTAGONIST BINDING-SITES; SENILE DEMENTIA; LOCUS-COERULEUS; CELL-DEATH; NEURONS; DIAGNOSIS; FOREBRAIN; RECEPTORS; CORTEX; CA1;
Keywords:
Alzheimer's disease; dihydropyridine; calcium channel; receptor autoradiography; receptor binding; hippocampal formation; CA1; dentate gyrus; [H-3]PN200-110; isradipine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Booze, RM Univ Kentucky, Dept Anat & Neurobiol, 800 Rose St, Lexington, KY40536 USA Univ Kentucky 800 Rose St Lexington KY USA 40536 n, KY 40536 USA
Citazione:
A.L. Coon et al., "L-type calcium channels in the hippocampus and cerebellum of Alzheimer's disease brain tissue", NEUROBIOL A, 20(6), 1999, pp. 597-603

Abstract

There is growing evidence that the selective neuronal cell death observed in Alzheimer's Disease (AD) is the result of dysregulation of intracellularcalcium (Ca2+) homeostasis. In the present study, L-type voltage sensitivecalcium channels (L-VSCCs) were examined in the cerebellum and hippocampusof AD (n = 6; postmortem interval less than 5 h) and age-matched control (n = 6) tissue by homogenate binding techniques and quantitative in vitro receptor autoradiography using [H-3]isradipine (PN200-110), saturation analyses of the cerebellum revealed unaltered [H-3]isradipine binding parameters (K-d and B-max) between AD and control subjects. Analysis of AD and controlhippocampus demonstrated significant differences as [H-3]isradipine binding increased (62%) in AD, whereas hippocampal cell density decreased (29%) in AD, relative to control subjects. Moreover, AD differentially affected L-VSCC in area CA1 and dentate gyrus. The dentate gyrus had greatly increasedbinding (77%) with little cell loss (16%) in AD brains, whereas area CA1 had increased binding (40%) with significant cell loss (42%) in AD brains, relative to controls. The results of the present study suggest that hippocampal area CAI may experience greater cell loss in response to increased L-VSCCs in AD relative to other brain regions. (C) 2000 Elsevier Science Inc. All rights reserved.

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Documento generato il 26/11/20 alle ore 20:08:04