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Titolo:
Antipsychotic drug-induced obesity in rats: correlation between leptin, insulin and body weight during sulpiride treatment
Autore:
Lacruz, A; Baptista, T; de Mendoza, S; Mendoza-Guillen, JM; Hernandez, L;
Indirizzi:
Univ Los Andes, Sch Med, Lab Behav Physiol, Merida, Venezuela Univ Los Andes Merida Venezuela d, Lab Behav Physiol, Merida, Venezuela Metab Ctr, Merida, Venezuela Metab Ctr Merida VenezuelaMetab Ctr, Merida, Venezuela
Titolo Testata:
MOLECULAR PSYCHIATRY
fascicolo: 1, volume: 5, anno: 2000,
pagine: 70 - 76
SICI:
1359-4184(200001)5:1<70:ADOIRC>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENE-EXPRESSION; FEMALE RATS; FOOD-INTAKE; PREVALENCE; MECHANISM; INCREASE; GAIN; ADIPOCYTES; ONSET;
Keywords:
leptin; insulin; glucose; prolactin; weight gain; antipsychotic drugs; rats; sulpiride;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Baptista, T Apartado 93, Merida 5101A, Venezuela Apartado 93 Merida Venezuela 5101A , Merida 5101A, Venezuela
Citazione:
A. Lacruz et al., "Antipsychotic drug-induced obesity in rats: correlation between leptin, insulin and body weight during sulpiride treatment", MOL PSYCHI, 5(1), 2000, pp. 70-76

Abstract

Sulpiride (SUL, 20 mg kg(-1) day(-1)) induces weight gain, hyperphagia, hyperprolactinemia, hypogonadism, and perhaps increased insulin sensitivity in rats. Leptin seems to signal the brain about the size of body fat stores and nutrient metabolism We evaluated the basal serum leptin levels in rats after acute (1 h) or prolonged SUL or vehicle administration (10, 20 and 30days). At days 10 and 30 leptin was also assessed during a glucose overload test. As the maximal weight gain during SUL administration is observed atdays 10-15 of treatment, leptin was measured in a comparison group of insulin-treated rats (5 IU day(-1) for 10 days). SUL-treated rats significantlygained weight. However, leptin levels were not significantly increased at any time-point of treatment. SUL did not affect insulin revels either. By contrast, leptin revels were significantly elevated after insulin administration, along with weight gain and hyperinsulinemia. An opposite correlation was also observed at day 10: leptin and insulin correlated negatively in the SUL group and positively in the insulin group. In addition, leptin and the magnitude of weight gain tended to correlate positively after SUL treatment, but negatively after insulin administration. SUL-treated rats, thus, appear to exhibit an unusual type of weight gain, characterized by normal circulating leptin and insulin levels. Such a particular leptin profile may berelated to hyperprolactinemia, hypogonadism or lack of hyperinsulinemia.

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Documento generato il 07/04/20 alle ore 22:57:45