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Titolo:
Dopamine induces a biphasic modulation of hypothalamic ANF neurons: a ligand concentration-dependent effect involving D-5 and D-2 receptor interaction
Autore:
Lee, D; Huang, W; Lim, AT;
Indirizzi:
Mental Hlth Res Inst, Div Mol Schizophrenia, Cell Biol Lab, Parkville, Vic3052, Australia Mental Hlth Res Inst Parkville Vic Australia 3052 lle, Vic3052, Australia Monash Univ, Dept Psychol Med, Clayton, Vic 3168, Australia Monash Univ Clayton Vic Australia 3168 Med, Clayton, Vic 3168, Australia
Titolo Testata:
MOLECULAR PSYCHIATRY
fascicolo: 1, volume: 5, anno: 2000,
pagine: 39 - 48
SICI:
1359-4184(200001)5:1<39:DIABMO>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
MESSENGER-RNA EXPRESSION; NATRIURETIC PEPTIDE-(5-28) PRODUCTION; G(S)-STIMULATED ADENYLYL CYCLASES; RAT-BRAIN; SECRETION; CULTURE; SCHIZOPHRENIA; DIVERSITY; SUBTYPES; GLUCOCORTICOIDS;
Keywords:
dopamine receptor subtypes; atrial natriuretic factor producing neurons; G proteins; adenylyl cyclases; primary neuron cultures; triple staining; receptor gene co-expression; CHO cells;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Lim, AT Mental Hlth Res Inst, Div Mol Schizophrenia, Cell Biol Lab, 155 Oak St, Parkville, Vic 3052, Australia Mental Hlth Res Inst 155 Oak St Parkville Vic Australia 3052 ralia
Citazione:
D. Lee et al., "Dopamine induces a biphasic modulation of hypothalamic ANF neurons: a ligand concentration-dependent effect involving D-5 and D-2 receptor interaction", MOL PSYCHI, 5(1), 2000, pp. 39-48

Abstract

Increasing evidence now suggests that more than one subtype of dopamine receptors is co-expressed in some of the central neurons, The neurobiologicaleffects on the host cells when these receptors are concurrently activated by their common physiological ligand, dopamine, however, remains elusive. Among the members of the family of dopamine receptors, coupling of D-1-like dopamine receptors to Gs and D-2-like receptors to Gi proteins are known toaugment or suppress cellular functions respectively, through modulation ofadenylyl cyclase activity and consequently cAMP generation, Simultaneous activation of D-1 and D-2 receptors in transfected cell lines expressing thetwo cloned receptors, however, produced antagonistic effects, This is in contrast to in vivo studies, in which concurrent activation of D-1-like and D-2-like receptors by their respective agonists may induce synergistic or antagonistic effects or both, We report here that in long-term rat hypothalamic cell cultures, activation of both D-1-like (D-1 and D-5) and D-2 receptors on atrial natriuretic factor-producing neurons by dopamine yields a biphasic response. The response is ligand concentration-dependent and involvestype II adenylyl cyclases, This process is mediated primarily through antagonistic and synergistic interactions of D-5 and D-2 receptors as the eventis mimicked by the concurrent activation of these two receptors co-transfected in CHO cells, Our present findings suggest a novel action of dopamine,and the biochemical processes involved may underlie some of the pharmacological actions of atypical anti-psychotic drugs.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 04:34:34