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Titolo:
The human serotonin transporter gene linked polymorphism (5-HTTLPR) shows ten novel allelic variants
Autore:
Nakamura, M; Ueno, S; Sano, A; Tanabe, H;
Indirizzi:
Ehime Univ, Sch Med, Dept Neuropsychiat, Shigenobu, Ehime 7910295, Japan Ehime Univ Shigenobu Ehime Japan 7910295 Shigenobu, Ehime 7910295, Japan
Titolo Testata:
MOLECULAR PSYCHIATRY
fascicolo: 1, volume: 5, anno: 2000,
pagine: 32 - 38
SICI:
1359-4184(200001)5:1<32:THSTGL>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
FUNCTIONAL POLYMORPHISM; REGULATORY REGION; DISORDER; ASSOCIATION; PROMOTER;
Keywords:
serotonin transporter; functional polymorphism; novel alleles; ethnic difference;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Sano, A Ehime Univ, Sch Med, Dept Neuropsychiat, Shigenobu, Ehime 7910295,Japan Ehime Univ Shigenobu Ehime Japan 7910295 bu, Ehime 7910295, Japan
Citazione:
M. Nakamura et al., "The human serotonin transporter gene linked polymorphism (5-HTTLPR) shows ten novel allelic variants", MOL PSYCHI, 5(1), 2000, pp. 32-38

Abstract

The serotonin transporter (5-HTT) gene is a promising candidate for introducing the heritability of interindividual variation in personality and the genetic susceptibility for various psychiatric diseases. Transcription of the gene is modulated by a common polymorphism in its upstream regulatory region (5-HTT gene-linked polymorphic region: 5-HTTtPR). The 5-HTTLPR consists of variation of the repetitive sequence containing GC-rich, 20-23-bp-longrepeat elements. A deletion/insertion in the 5-HTTLPR was first reported to create a short (S) allele and a long (L) allele (14- and 16-repeats, respectively). Three other kinds of alleles (18-, 19- and 20-repeats) in addition to the S and L alleles in 5-HTTLPR have been reported. In the present study, we examined the 5-HTTLPR polymorphism in detail and identified ten novel sequence variants, concluding that the alleles reported as S and L, are divided into four and six kinds of allelic variant, respectively. Subsequently, we developed a method for genotyping. The total number of alleles (14-A, 14-B, 14-C, 14-D, 15, 16-A, 16-B, 16-C, 16-D, 16-E, 16-F, 19, 20 and 22)in the 5-HTTLPR was 14 in our populations (Japanese: n = 131; Caucasian: n= 74) in the present study. In addition, a significant ethnic difference between Japanese and Caucasian populations was observed for distributions ofalleles and genotypes (P < 0.0001 and P < 0.0001, respectively). Our results suggest that the analyses of the 5-HTTLPR should be revised by genotyping with a more complete subdivision of alleles.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 10:07:39